Cannabis Compound Database: Showing Protein Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (CDBP00265)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP00265

Secondary Accession Numbers

Not Available

Name

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

Description

Not Available

Synonyms

Alpha-2,8-sialyltransferase 8A
Ganglioside GD3 synthase
Ganglioside GT3 synthase
SIAT8-A
ST8SiaI
Sialyltransferase 8A
Sialytransferase St8Sia I
Sialyltransferase St8Sia I

Gene Name

ST8SIA1

Protein Type

Enzyme

Biological Properties

General Function

Involved in sialyltransferase activity

Specific Function

Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid.

GO Classification

Biological Process
positive regulation of cell proliferation
glycosphingolipid biosynthetic process
protein glycosylation
carbohydrate metabolic process
cellular response to heat
Cellular Component
integral to Golgi membrane
integral to membrane
Component
cell part
membrane part
intrinsic to membrane
intrinsic to organelle membrane
intrinsic to golgi membrane
integral to golgi membrane
Function
sialyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
Molecular Function
sialyltransferase activity
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid glycosylation

Cellular Location

Golgi apparatus membrane
Single-pass type II membrane protein (Potential)

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein glycosylation	Not Available	Not Available
Glycosphingolipid biosynthesis - lacto and neolacto series	Not Available
Glycosphingolipid biosynthesis - globo series	Not Available
Glycosphingolipid biosynthesis - ganglio series	Not Available

Gene Properties

Chromosome Location

Locus

12p12.1-p11.2

SNPs

ST8SIA1

Gene Sequence

>1071 bp
ATGAGCCCCTGCGGGCGGGCCCGGCGACAAACGTCCAGAGGGGCCATGGCTGTACTGGCG
TGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTC
TGTTGGCTCTACATCTTCCCCGTCTACCGGCTGCCCAACGAGAAAGAGATCGTGCAGGGG
GTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCAGACCGCGGCCAGAGCGTTCAGGAAA
CAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCT
ATGGGGAAGAGCATGTGGTATGACGGGGAGTTTTTATACTCATTCACCATTGACAATTCA
ACTTACTCTCTCTTCCCACAGGCAACCCCATTCCAGCTGCCATTGAAGAAATGCGCGGTG
GTGGGAAATGGTGGGATTCTGAAGAAGAGTGGCTGTGGCCGTCAAATAGATGAAGCAAAT
TTTGTCATGCGATGCAATCTCCCTCCTTTGTCAAGTGAATACACTAAGGATGTTGGATCC
AAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTTTCAGAACCTTCTG
TGGTCCAGAAAGACATTTGTGGACAACATGAAAATCTATAACCACAGTTACATCTACATG
CCTGCCTTTTCTATGAAGACAGGAACAGAGCCATCTTTGAGGGTTTATTATACACTGTCA
GATGTTGGTGCCAATCAAACAGTGCTGTTTGCCAACCCCAACTTTCTGCGTAGCATTGGA
AAGTTCTGGAAAAGTAGAGGAATCCATGCCAAGCGCCTGTCCACAGGACTTTTTCTGGTG
AGCGCAGCTCTGGGTCTCTGTGAAGAGGTGGCCATCTATGGCTTCTGGCCCTTCTCTGTG
AATATGCATGAGCAGCCCATCAGCCACCACTACTATGACAACGTCTTACCCTTTTCTGGC
TTCCATGCCATGCCCGAGGAATTTCTCCAACTCTGGTATCTTCATAAAATCGGTGCACTG
AGAATGCAGCTGGACCCATGTGAAGATACCTCACTCCAGCCCACTTCCTAG

Protein Properties

Number of Residues

356

Molecular Weight

40518.655

Theoretical pI

9.292

Pfam Domain Function

Glyco_transf_29 (PF00777 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQG
VLQQGTAWRRNQTAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNS
TYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGS
KSQLVTANPSIIRQRFQNLLWSRKTFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLS
DVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSV
NMHEQPISHHYYDNVLPFSGFHAMPEEFLQLWYLHKIGALRMQLDPCEDTSLQPTS

External Links

GenBank ID Protein

510988

UniProtKB/Swiss-Prot ID

Q92185

UniProtKB/Swiss-Prot Entry Name

SIA8A_HUMAN

PDB IDs

Not Available

GenBank Gene ID

X77922

GeneCard ID