| Identification |
|---|
| HMDB Protein ID
| CDBP00261 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphoglycerate mutase 2 |
| Description
| Not Available |
| Synonyms
|
- BPG-dependent PGAM 2
- Muscle-specific phosphoglycerate mutase
- PGAM-M
- Phosphoglycerate mutase isozyme M
|
| Gene Name
| PGAM2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| spermatogenesis |
| striated muscle contraction |
| glycolysis |
| gluconeogenesis |
| response to mercury ion |
| Cellular Component |
| cytosol |
| nucleus |
| Function |
| intramolecular transferase activity, phosphotransferases |
| catalytic activity |
| isomerase activity |
| intramolecular transferase activity |
| Molecular Function |
| 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity |
| cofactor binding |
| bisphosphoglycerate 2-phosphatase activity |
| bisphosphoglycerate mutase activity |
| phosphoglycerate mutase activity |
| Process |
| metabolic process |
| small molecule metabolic process |
| alcohol metabolic process |
| monosaccharide metabolic process |
| hexose metabolic process |
| glucose metabolic process |
| glucose catabolic process |
| glycolysis |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycolysis / Gluconeogenesis | Not Available |  | | Glycine, serine and threonine metabolism | Not Available |  | | Glycolysis |    | | | Glycogenosis, Type VII. Tarui disease |    | Not Available | | Fanconi-bickel syndrome |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7p13-p12 |
| SNPs
| PGAM2 |
| Gene Sequence
|
>762 bp
ATGGCCACTCACCGCCTCGTGATGGTCCGGCACGGCGAGACGACATGGAACCAGGAGAAC
CGTTTCTGTGGCTGGTTCGATGCAGAGCTGAGTGAAAAGGGGACCGAGGAGGCCAAGCGG
GGAGCCAAGGCCATCAAGGATGCCAAGATGGAGTTTGACATCTGCTACACGTCAGTGCTG
AAGCGGGCCATCCGAACCCTCTGGGCCATCCTGGACGGCACGGACCAGATGTGGCTGCCT
GTGGTGCGCACTTGGCGCTTCAATGAGCGGCATTACGGGGGCCTCACAGGCTTCAACAAG
GCAGAAACGGCCGCCAAGCACGGGGAGGAGCAGGTAAGATCTTGGAGGCGCTCCTTCGAC
ATCCCGCCGCCCCCGATGGACGAGAAGCACCCCTACTACAACTCCATTAGCAAGGAGCGT
CGGTACGCAGGCCTGAAGCCCGGGGAACTCCCCACCTGCGAGAGCCTCAAGGACACCATT
GCCCGGGCCCTGCCCTTCTGGAACGAGGAGATTGTTCCCCAGATCAAGGCCGGCAAGCGA
GTGCTCATTGCAGCCCACGGGAACAGCCTGCGGGGCATTGTCAAGCACCTGGAAGGGATG
TCAGACCAGGCGATCATGGAGCTGAACCTGCCCACGGGGATCCCCATTGTGTATGAGCTG
AACAAGGAGCTGAAGCCCACCAAGCCCATGCAGTTCCTGGGTGATGAGGAAACGGTGCGG
AAGGCCATGGAGGCTGTGGCTGCCCAGGGCAAGGCCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 253 |
| Molecular Weight
| 28765.96 |
| Theoretical pI
| 8.887 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphoglycerate mutase 2
MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVL
KRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFD
IPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKR
VLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVR
KAMEAVAAQGKAK
|
| External Links |
|---|
| GenBank ID Protein
| 189868 |
| UniProtKB/Swiss-Prot ID
| P15259 |
| UniProtKB/Swiss-Prot Entry Name
| PGAM2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M18172 |
| GeneCard ID
| PGAM2 |
| GenAtlas ID
| PGAM2 |
| HGNC ID
| HGNC:8889 |
| References |
|---|
| General References
| Not Available |