| Identification |
|---|
| HMDB Protein ID
| CDBP00211 |
| Secondary Accession Numbers
| Not Available |
| Name
| Spermine synthase |
| Description
| Not Available |
| Synonyms
|
- SPMSY
- Spermidine aminopropyltransferase
|
| Gene Name
| SMS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in spermine synthase activity |
| Specific Function
| Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).
|
| GO Classification
|
| Biological Process |
| polyamine metabolic process |
| methionine metabolic process |
| spermine biosynthetic process |
| Cellular Component |
| cytosol |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring alkyl or aryl (other than methyl) groups |
| spermine synthase activity |
| Molecular Function |
| spermine synthase activity |
| spermidine synthase activity |
| Process |
| metabolic process |
| cellular metabolic process |
| cellular amino acid derivative metabolic process |
| cellular biogenic amine metabolic process |
| polyamine metabolic process |
| polyamine biosynthetic process |
| spermine biosynthetic process |
| cellular amino acid and derivative metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Spermidine and Spermine Biosynthesis |    | Not Available | | spermine biosynthesis | Not Available | Not Available | | Cysteine and methionine metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Xp22.1 |
| SNPs
| SMS |
| Gene Sequence
|
>1101 bp
ATGGCAGCAGCACGGCACAGCACGCTCGACTTCATGCTCGGCGCCAAAGCTGATGGTGAG
ACCATTCTAAAAGGCCTCCAGTCCATTTTCCAGGAGCAGGGGATGGCGGAGTCGGTGCAC
ACCTGGCAGGACCATGGCTATTTAGCAACCTACACAAACAAGAACGGCAGCTTTGCCAAT
TTGAGAATTTACCCACATGGATTGGTGTTGCTGGACCTTCAGAGTTATGATGGTGATGCG
CAAGGCAAAGAAGAGATCGACAGTATTTTGAACAAAGTAGAGGAAAGAATGAAAGAATTG
AGTCAGGACAGTACTGGGCGGGTGAAACGATTACCACCCATAGTGCGAGGAGGAGCCATC
GACAGATACTGGCCCACCGCCGACGGGCGCCTGGTTGAATATGACATAGATGAAGTGGTA
TATGACGAAGATTCACCTTATCAAAATATAAAAATTCTACACTCGAAGCAGTTTGGAAAT
ATTCTCATCCTTAGTGGGGATGTTAATTTGGCAGAGAGTGATTTGGCATATACCCGGGCC
ATCATGGGCAGTGGCAAAGAAGATTACACTGGCAAAGATGTACTCATTCTGGGAGGTGGA
GACGGAGGCATATTGTGTGAAATAGTCAAACTAAAACCAAAGATGGTCACTATGGTAGAG
ATTGACCAAATGGTGATTGATGGGTGTAAGAAATACATGCGAAAAACGTGTGGCGATGTC
TTAGACAATCTTAAAGGAGACTGCTATCAGGTTCTAATAGAAGACTGTATCCCGGTACTG
AAGAGGTACGCCAAAGAAGGGAGAGAATTTGATTATGTGATTAATGATTTGACAGCTGTT
CCAATCTCCACGTCTCCAGAAGAAGATTCCACATGGGAGTTTCTCAGACTGATTCTTGAC
CTCTCAATGAAAGTGTTGAAACAGGATGGGAAATATTTTACACAGGGGAACTGTGTCAAT
CTGACAGAAGCACTGTCGCTCTATGAAGAACAGCTGGGGCGCCTGTATTGTCCTGTGGAA
TTTTCAAAGGAGATCGTCTGTGTCCCTTCATACTTGGAATTGTGGGTATTTTACACTGTT
TGGAAGAAAGCTAAACCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 366 |
| Molecular Weight
| 35278.2 |
| Theoretical pI
| 5.018 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Spermine synthase
MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFAN
LRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAI
DRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRA
IMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDV
LDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILD
LSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTV
WKKAKP
|
| External Links |
|---|
| GenBank ID Protein
| 2198557 |
| UniProtKB/Swiss-Prot ID
| P52788 |
| UniProtKB/Swiss-Prot Entry Name
| SPSY_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AD001528 |
| GeneCard ID
| SMS |
| GenAtlas ID
| SMS |
| HGNC ID
| HGNC:11123 |
| References |
|---|
| General References
| Not Available |