| Identification |
|---|
| HMDB Protein ID
| CDBP00204 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glucokinase |
| Description
| Not Available |
| Synonyms
|
- HK IV
- HK4
- Hexokinase type IV
- Hexokinase-4
- Hexokinase-D
|
| Gene Name
| GCK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
|
| GO Classification
|
| Biological Process |
| NADP metabolic process |
| positive regulation of glycolysis |
| glycolysis |
| glucose transport |
| small molecule metabolic process |
| elevation of cytosolic calcium ion concentration |
| endocrine pancreas development |
| cellular response to leptin stimulus |
| positive regulation of insulin secretion |
| detection of glucose |
| cellular response to insulin stimulus |
| negative regulation of epinephrine secretion |
| calcium ion import |
| negative regulation of gluconeogenesis |
| cellular glucose homeostasis |
| positive regulation of glycogen biosynthetic process |
| fructose 2,6-bisphosphate metabolic process |
| positive regulation of phosphorylation |
| glycogen biosynthetic process |
| cellular response to glucose starvation |
| transmembrane transport |
| regulation of glucose transport |
| regulation of glycolysis |
| regulation of potassium ion transport |
| second-messenger-mediated signaling |
| Cellular Component |
| nucleoplasm |
| secretory granule |
| cytosol |
| actin filament |
| cell cortex part |
| mitochondrion |
| Function |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| phosphotransferase activity, alcohol group as acceptor |
| hexokinase activity |
| Molecular Function |
| glucokinase activity |
| ADP binding |
| magnesium ion binding |
| glucose binding |
| ATP binding |
| Process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
| small molecule metabolic process |
| alcohol metabolic process |
| monosaccharide metabolic process |
| hexose metabolic process |
| glucose metabolic process |
| glucose catabolic process |
| glycolysis |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycolysis / Gluconeogenesis | Not Available |  | | Amino sugar and nucleotide sugar metabolism | Not Available |  | | Butirosin and neomycin biosynthesis | Not Available |  | | Insulin signaling pathway | Not Available |  | | Insulin secretion | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7p15.3-p15.1 |
| SNPs
| GCK |
| Gene Sequence
|
>1398 bp
ATGCTGGACGACAGAGCCAGGATGGAGGCCGCCAAGAAGGAGAAGGTAGAGCAGATCCTG
GCAGAGTTCCAGCTGCAGGAGGAGGACCTGAAGAAGGTGATGAGACGGATGCAGAAGGAG
ATGGACCGCGGCCTGAGGCTGGAGACCCATGAAGAGGCCAGTGTGAAGATGCTGCCCACC
TACGTGCGCTCCACCCCAGAAGGCTCAGAAGTCGGGGACTTCCTCTCCCTGGACCTGGGT
GGCACTAACTTCAGGGTGATGCTGGTGAAGGTGGGAGAAGGTGAGGAGGGGCAGTGGAGC
GTGAAGACCAAACACCAGATGTACTCCATCCCCGAGGACGCCATGACCGGCACTGCTGAG
ATGCTCTTCGACTACATCTCTGAGTGCATCTCCGACTTCCTGGACAAGCATCAGATGAAA
CACAAGAAGCTGCCCCTGGGCTTCACCTTCTCCTTTCCTGTGAGGCACGAAGACATCGAT
AAGGGCATCCTTCTCAACTGGACCAAGGGCTTCAAGGCCTCAGGAGCAGAAGGGAACAAT
GTCGTGGGGCTTCTGCGAGACGCTATCAAACGGAGAGGGGACTTTGAAATGGATGTGGTG
GCAATGGTGAATGACACGGTGGCCACGATGATCTCCTGCTACTACGAAGACCATCAGTGC
GAGGTCGGCATGATCGTGGGCACGGGCTGCAATGCCTGCTACATGGAGGAGATGCAGAAT
GTGGAGCTGGTGGAGGGGGACGAGGGCCGCATGTGCGTCAATACCGAGTGGGGCGCCTTC
GGGGACTCCGGCGAGCTGGACGAGTTCCTGCTGGAGTATGACCGCCTGGTGGACGAGAGC
TCTGCAAACCCCGGTCAGCAGCTGTATGAGAAGCTCATAGGTGGCAAGTACATGGGCGAG
CTGGTGCGGCTTGTGCTGCTCAGGCTCGTGGACGAAAACCTGCTCTTCCACGGGGAGGCC
TCCGAGCAGCTGCGCACACGCGGAGCCTTCGAGACGCGCTTCGTGTCGCAGGTGGAGAGC
GACACGGGCGACCGCAAGCAGATCTACAACATCCTGAGCACGCTGGGGCTGCGACCCTCG
ACCACCGACTGCGACATCGTGCGCCGCGCCTGCGAGAGCGTGTCTACGCGCGCTGCGCAC
ATGTGCTCGGCGGGGCTGGCGGGCGTCATCAACCGCATGCGCGAGAGCCGCAGCGAGGAC
GTAATGCGCATCACTGTGGGCGTGGATGGCTCCGTGTACAAGCTGCACCCCAGCTTCAAG
GAGCGGTTCCATGCCAGCGTGCGCAGGCTGACGCCCAGCTGCGAGATCACCTTCATCGAG
TCGGAGGAGGGCAGTGGCCGGGGCGCGGCCCTGGTCTCGGCGGTGGCCTGTAAGAAGGCC
TGTATGCTGGGCCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 465 |
| Molecular Weight
| 52191.07 |
| Theoretical pI
| 5.203 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glucokinase
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
|
| External Links |
|---|
| GenBank ID Protein
| 179427 |
| UniProtKB/Swiss-Prot ID
| P35557 |
| UniProtKB/Swiss-Prot Entry Name
| HXK4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M88011 |
| GeneCard ID
| GCK |
| GenAtlas ID
| GCK |
| HGNC ID
| HGNC:4195 |
| References |
|---|
| General References
| Not Available |