| Identification |
|---|
| HMDB Protein ID
| CDBP00203 |
| Secondary Accession Numbers
| Not Available |
| Name
| L-dopachrome tautomerase |
| Description
| Not Available |
| Synonyms
|
- DCT
- DT
- L-dopachrome Delta-isomerase
- TRP-2
- TRP2
- Tyrosinase-related protein 2
|
| Gene Name
| DCT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Involved in regulating eumelanin and phaeomelanin levels.
|
| GO Classification
|
| Biological Process |
| melanin biosynthetic process from tyrosine |
| developmental pigmentation |
| positive regulation of neuroblast proliferation |
| ventricular zone neuroblast division |
| cell development |
| oxidation-reduction process |
| epidermis development |
| Cellular Component |
| cytosol |
| melanosome membrane |
| melanosome |
| integral to membrane |
| Function |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| oxidoreductase activity |
| dopachrome isomerase activity |
| copper ion binding |
| Process |
| metabolic process |
|
| Cellular Location
|
- Melanosome membrane
- Single-pass type I membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Tyrosine Metabolism |    |  | | melanin biosynthesis | Not Available | Not Available | | Melanogenesis | Not Available |  | | Alkaptonuria |    | Not Available | | Hawkinsinuria |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| 13q32 |
| SNPs
| DCT |
| Gene Sequence
|
>1560 bp
ATGAGCCCCCTTTGGTGGGGGTTTCTGCTCAGTTGCTTGGGCTGCAAAATCCTGCCAGGA
GCCCAGGGTCAGTTCCCCCGAGTCTGCATGACGGTGGACAGCCTAGTGAACAAGGAGTGC
TGCCCACGCCTGGGTGCAGAGTCGGCCAATGTCTGTGGCTCTCAGCAAGGCCGGGGGCAG
TGCACAGAGGTGCGAGCCGACACAAGGCCCTGGAGTGGTCCCTACATCCTACGAAACCAG
GATGACCGTGAGCTGTGGCCAAGAAAATTCTTCCACCGGACCTGCAAGTGCACAGGAAAC
TTTGCCGGCTATAATTGTGGAGACTGCAAGTTTGGCTGGACCGGTCCCAACTGCGAGCGG
AAGAAACCACCAGTGATTCGGCAGAACATCCATTCCTTGAGTCCTCAGGAAAGAGAGCAG
TTCTTGGGCGCCTTAGATCTCGCGAAGAAGAGAGTACACCCCGACTACGTGATCACCACA
CAACACTGGCTGGGCCTGCTTGGGCCCAATGGAACCCAGCCGCAGTTTGCCAACTGCAGT
GTTTATGATTTTTTTGTGTGGCTCCATTATTATTCTGTTAGAGATACATTATTAGGACCA
GGACGCCCCTACAGGGCCATAGATTTCTCACATCAAGGACCTGCATTTGTTACCTGGCAC
CGGTACCATTTGTTGTGTCTGGAAAGAGATCTCCAGCGACTCATTGGCAATGAGTCTTTT
GCTTTGCCCTACTGGAACTTTGCCACTGGGAGGAACGAGTGTGATGTGTGTACAGACCAG
CTGTTTGGGGCAGCGAGACCAGACGATCCGACTCTGATTAGTCGGAACTCAAGATTCTCC
AGCTGGGAAACTGTCTGTGATAGCTTGGATGACTACAACCACCTGGTCACCTTGTGCAAT
GGAACCTATGAAGGTTTGCTGAGAAGAAATCAAATGGGAAGAAACAGCATGAAATTGCCA
ACCTTAAAAGACATACGAGATTGCCTGTCTCTCCAGAAGTTTGACAATCCTCCCTTCTTC
CAGAACTCTACCTTCAGTTTCAGGAATGCTTTGGAAGGGTTTGATAAAGCAGATGGGACT
CTGGATTCTCAAGTGATGAGCCTTCATAATTTGGTTCATTCCTTCCTGAACGGGACAAAC
GCTTTGCCACATTCAGCCGCCAATGATCCCATTTTTGTGGTTCTTCATTCCTTTACTGAT
GCCATCTTTGATGAGTGGATGAAAAGATTTAATCCTCCTGCAGATGCCTGGCCTCAGGAG
CTGGCCCCTATTGGTCACAATCGGATGTACAACATGGTTCCTTTCTTCCCTCCAGTGACT
AATGAAGAACTCTTTTTAACCTCAGACCAACTTGGCTACAGCTATGCCATCGATCTGCCA
GTTTCAGTTGAAGAAACTCCAGGTTGGCCCACAACTCTCTTAGTAGTCATGGGAACACTG
GTGGCTTTGGTTGGTCTTTTTGTGCTGTTGGCTTTTCTTCAATATAGAAGACTTCGAAAA
GGATATACACCCCTAATGGAGACACATTTAAGCAGCAAGAGATACACAGAAGAAGCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 519 |
| Molecular Weight
| 62928.215 |
| Theoretical pI
| 7.435 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>L-dopachrome tautomerase
MSPLWWGFLLSCLGCKILPGAQGQFPRVCMTVDSLVNKECCPRLGAESANVCGSQQGRGQ
CTEVRADTRPWSGPYILRNQDDRELWPRKFFHRTCKCTGNFAGYNCGDCKFGWTGPNCER
KKPPVIRQNIHSLSPQEREQFLGALDLAKKRVHPDYVITTQHWLGLLGPNGTQPQFANCS
VYDFFVWLHYYSVRDTLLGPGRPYRAIDFSHQGPAFVTWHRYHLLCLERDLQRLIGNESF
ALPYWNFATGRNECDVCTDQLFGAARPDDPTLISRNSRFSSWETVCDSLDDYNHLVTLCN
GTYEGLLRRNQMGRNSMKLPTLKDIRDCLSLQKFDNPPFFQNSTFSFRNALEGFDKADGT
LDSQVMSLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDAIFDEWMKRFNPPADAWPQE
LAPIGHNRMYNMVPFFPPVTNEELFLTSDQLGYSYAIDLPVSVEETPGWPTTLLVVMGTL
VALVGLFVLLAFLQYRRLRKGYTPLMETHLSSKRYTEEA
|
| External Links |
|---|
| GenBank ID Protein
| 12313911 |
| UniProtKB/Swiss-Prot ID
| P40126 |
| UniProtKB/Swiss-Prot Entry Name
| TYRP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL139318 |
| GeneCard ID
| DCT |
| GenAtlas ID
| DCT |
| HGNC ID
| HGNC:2709 |
| References |
|---|
| General References
| Not Available |