<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <id type="integer">177</id>
  <cancdbp-id>CDBP00176</cancdbp-id>
  <name>Xanthine dehydrogenase/oxidase</name>
  <uniprot-id>P47989</uniprot-id>
  <uniprot-name>XDH_HUMAN</uniprot-name>
  <enzyme type="boolean">true</enzyme>
  <transporter type="boolean">false</transporter>
  <protein-type>Enzyme</protein-type>
  <organism>Homo_sapiens</organism>
  <gene-name>XDH</gene-name>
  <num-residues type="integer">1333</num-residues>
  <molecular-weight type="decimal">146422.99</molecular-weight>
  <theoretical-pi type="decimal">7.663</theoretical-pi>
  <general-function>Involved in oxidoreductase activity</general-function>
  <specific-function>Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).
</specific-function>
  <signal-regions type="array"/>
  <transmembrane-regions type="array"/>
  <pdb-ids>2CKJ;2E1Q</pdb-ids>
  <genbank-gene-id>D11456</genbank-gene-id>
  <genbank-protein-id nil="true"/>
  <genecard-id>XDH</genecard-id>
  <chromosome-location>2</chromosome-location>
  <locus>2p23.1</locus>
  <geneatlas-id>XDH</geneatlas-id>
  <hgnc-id>HGNC:12805</hgnc-id>
  <export type="boolean">true</export>
  <comment nil="true"/>
  <kegg-id>hsa:7498</kegg-id>
  <meta-cyc-id>HS08270-MONOMER</meta-cyc-id>
  <ncbi-sequence-ids>NP_000370.2:NM_000379.3</ncbi-sequence-ids>
  <tissue-specificity>Detected in milk (at protein level).
</tissue-specificity>
  <cofactor>2Fe-2S clusters;FAD;molybdenum ion (molybdopterin)</cofactor>
  <subunit>Homodimer. Interacts with BTN1A1
</subunit>
  <cellular-location nil="true"/>
  <ec-number nil="true"/>
  <created-at type="dateTime">2020-06-12T23:06:48Z</created-at>
  <updated-at type="dateTime">2020-07-28T02:24:57Z</updated-at>
  <description nil="true"/>
  <receptor type="integer">0</receptor>
  <metal-binding type="integer">1</metal-binding>
  <trans-factor type="integer">0</trans-factor>
</protein>

