<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <id type="integer">116</id>
  <cancdbp-id>CDBP00115</cancdbp-id>
  <name>NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial</name>
  <uniprot-id>O75306</uniprot-id>
  <uniprot-name>NDUS2_HUMAN</uniprot-name>
  <enzyme type="boolean">true</enzyme>
  <transporter type="boolean">false</transporter>
  <protein-type>Enzyme</protein-type>
  <organism>Homo_sapiens</organism>
  <gene-name>NDUFS2</gene-name>
  <num-residues type="integer">463</num-residues>
  <molecular-weight type="decimal">51851.59</molecular-weight>
  <theoretical-pi type="decimal">8.145</theoretical-pi>
  <general-function>Involved in oxidoreductase activity, acting on NADH or NADPH</general-function>
  <specific-function>Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
</specific-function>
  <signal-regions type="array"/>
  <transmembrane-regions type="array"/>
  <pdb-ids></pdb-ids>
  <genbank-gene-id>AF050640</genbank-gene-id>
  <genbank-protein-id nil="true"/>
  <genecard-id>NDUFS2</genecard-id>
  <chromosome-location>1</chromosome-location>
  <locus>1q23</locus>
  <geneatlas-id>NDUFS2</geneatlas-id>
  <hgnc-id>HGNC:7708</hgnc-id>
  <export type="boolean">true</export>
  <comment nil="true"/>
  <kegg-id>hsa:4720</kegg-id>
  <meta-cyc-id></meta-cyc-id>
  <ncbi-sequence-ids>NP_001159631.1:NM_001166159.1;NP_004541.1:NM_004550.4</ncbi-sequence-ids>
  <tissue-specificity></tissue-specificity>
  <cofactor>4Fe-4S cluster</cofactor>
  <subunit>Complex I is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme. Interacts with NDUFAF3 and NDUFAF7
</subunit>
  <cellular-location nil="true"/>
  <ec-number nil="true"/>
  <created-at type="dateTime">2020-06-12T23:06:47Z</created-at>
  <updated-at type="dateTime">2020-07-28T02:24:54Z</updated-at>
  <description nil="true"/>
  <receptor type="integer">0</receptor>
  <metal-binding type="integer">1</metal-binding>
  <trans-factor type="integer">0</trans-factor>
</protein>

