115 CDBP00114 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 P22413 ENPP1_HUMAN true false Enzyme Homo_sapiens ENPP1 925 104923.58 7.136 Involved in catalytic activity Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity. 2YS0 NM_006208.2 170650661 ENPP1 6 6q22-q23 ENPP1 HGNC:3356 true hsa:5167 NP_006199.2:NM_006208.2 Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis. divalent metal cations Homodimer; disulfide-linked. Interacts with INSR 2020-06-12T23:06:47Z 2020-07-28T02:24:54Z 1 1 0