Identification
HMDB Protein ID CDBP00089
Secondary Accession Numbers Not Available
Name Serum paraoxonase/arylesterase 2
Description Not Available
Synonyms
  1. A-esterase 2
  2. Aromatic esterase 2
  3. PON 2
  4. Serum aryldialkylphosphatase 2
  5. SubName: cDNA FLJ78444, highly similar to Homo sapiens paraoxonase 2, transcript variant 1, mRNA
Gene Name PON2
Protein Type Enzyme
Biological Properties
General Function Involved in arylesterase activity
Specific Function Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
GO Classification
Biological Process
aromatic compound catabolic process
response to oxidative stress
Cellular Component
mitochondrion
plasma membrane
nucleus
lysosome
extracellular region
Component
extracellular region
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
carboxylesterase activity
arylesterase activity
Molecular Function
metal ion binding
arylesterase activity
identical protein binding
Cellular Location
  1. Cytoplasmic
  2. Peripheral membrane protein
  3. Membrane
Pathways
Gene Properties
Chromosome Location 7
Locus 7q21.3
SNPs PON2
Gene Sequence
>1065 bp
ATGGGGGCCTGGGTGGGCTGTGGGCTTGCTGGGGATCGCGCTGGCTTCCTGGGCGAGAGG
CTTCTGGCACTCAGAAATCGACTTAAAGCCTCCAGAGAAGTAGAATCTGTAGACCTTCCA
CACTGCCACCTGATTAAAGGAATTGAAGCTGGCTCTGAAGATATTGACATACTTCCCAAT
GGTCTGGCTTTTTTTAGTGTGGGTCTAAAATTCCCAGGACTCCACAGCTTTGCACCAGAT
AAGCCTGGAGGAATACTAATGATGGATCTAAAAGAAGAAAAACCAAGGGCACGGGAATTA
AGAATCAGTCGTGGGTTTGATTTGGCCTCATTCAATCCACATGGCATCAGCACTTTCATA
GACAACGATGACACAGTTTATCTCTTTGTTGTAAACCACCCAGAATTCAAGAATACAGTG
GAAATTTTTAAATTTGAAGAAGCAGAAAATTCTCTGTTGCATCTGAAAACAGTCAAACAT
GAGCTTCTTCCAAGTGTGAATGACATCACAGCTGTTGGACCGGCACATTTCTATGCCACA
AATGACCACTACTTCTCTGATCCTTTCTTAAAGTATTTAGGAACATACTTGAACTTACAC
TGGGCAAATGTTGTTTACTACAGTCCAAATGAAGTTAAAGTGGTAGCAGAAGGATTTGAT
TCAGCAAATGGGATCAATATTTCACCTGATGATAAGTATATCTATGTTGCTGACATATTG
GCTCATGAAATTCATGTTTTGGAAAAACACACTAATATGAATTTAACTCAGTTGAAGGTA
CTTGAGCTGGATACACTGGTGGATAATTTATCTATTGATCCTTCCTCGGGGGACATCTGG
GTAGGCTGTCATCCTAATGGCCAGAAGCTCTTCGTGTATGACCCGAACAATCCTCCCTCG
TCAGAGGTTCTCCGCATCCAGAACATTCTATGTGAGAAGCCTACAGTGACTACAGTTTAT
GCCAACAATGGGTCTGTTCTCCAAGGAAGTTCTGTAGCCTCAGTGTATGATGGGAAGCTG
CTCATAGGCACTTTATACCACAGAGCCTTGTATTGTGAACTCTAA
Protein Properties
Number of Residues 354
Molecular Weight 39380.535
Theoretical pI 5.599
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Serum paraoxonase/arylesterase 2
MGAWVGCGLAGDRAGFLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN
GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI
DNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYAT
NDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADIL
AHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPS
SEVLRIQNILCEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL
GenBank ID Protein 1333632
UniProtKB/Swiss-Prot ID Q15165
UniProtKB/Swiss-Prot Entry Name PON2_HUMAN
PDB IDs Not Available
GenBank Gene ID L48513
GeneCard ID PON2
GenAtlas ID PON2
HGNC ID HGNC:9205
References
General References Not Available