| Identification |
|---|
| HMDB Protein ID
| CDBP00089 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serum paraoxonase/arylesterase 2 |
| Description
| Not Available |
| Synonyms
|
- A-esterase 2
- Aromatic esterase 2
- PON 2
- Serum aryldialkylphosphatase 2
- SubName: cDNA FLJ78444, highly similar to Homo sapiens paraoxonase 2, transcript variant 1, mRNA
|
| Gene Name
| PON2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in arylesterase activity |
| Specific Function
| Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
|
| GO Classification
|
| Biological Process |
| aromatic compound catabolic process |
| response to oxidative stress |
| Cellular Component |
| mitochondrion |
| plasma membrane |
| nucleus |
| lysosome |
| extracellular region |
| Component |
| extracellular region |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| carboxylesterase activity |
| arylesterase activity |
| Molecular Function |
| metal ion binding |
| arylesterase activity |
| identical protein binding |
|
| Cellular Location
|
- Cytoplasmic
- Peripheral membrane protein
- Membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7q21.3 |
| SNPs
| PON2 |
| Gene Sequence
|
>1065 bp
ATGGGGGCCTGGGTGGGCTGTGGGCTTGCTGGGGATCGCGCTGGCTTCCTGGGCGAGAGG
CTTCTGGCACTCAGAAATCGACTTAAAGCCTCCAGAGAAGTAGAATCTGTAGACCTTCCA
CACTGCCACCTGATTAAAGGAATTGAAGCTGGCTCTGAAGATATTGACATACTTCCCAAT
GGTCTGGCTTTTTTTAGTGTGGGTCTAAAATTCCCAGGACTCCACAGCTTTGCACCAGAT
AAGCCTGGAGGAATACTAATGATGGATCTAAAAGAAGAAAAACCAAGGGCACGGGAATTA
AGAATCAGTCGTGGGTTTGATTTGGCCTCATTCAATCCACATGGCATCAGCACTTTCATA
GACAACGATGACACAGTTTATCTCTTTGTTGTAAACCACCCAGAATTCAAGAATACAGTG
GAAATTTTTAAATTTGAAGAAGCAGAAAATTCTCTGTTGCATCTGAAAACAGTCAAACAT
GAGCTTCTTCCAAGTGTGAATGACATCACAGCTGTTGGACCGGCACATTTCTATGCCACA
AATGACCACTACTTCTCTGATCCTTTCTTAAAGTATTTAGGAACATACTTGAACTTACAC
TGGGCAAATGTTGTTTACTACAGTCCAAATGAAGTTAAAGTGGTAGCAGAAGGATTTGAT
TCAGCAAATGGGATCAATATTTCACCTGATGATAAGTATATCTATGTTGCTGACATATTG
GCTCATGAAATTCATGTTTTGGAAAAACACACTAATATGAATTTAACTCAGTTGAAGGTA
CTTGAGCTGGATACACTGGTGGATAATTTATCTATTGATCCTTCCTCGGGGGACATCTGG
GTAGGCTGTCATCCTAATGGCCAGAAGCTCTTCGTGTATGACCCGAACAATCCTCCCTCG
TCAGAGGTTCTCCGCATCCAGAACATTCTATGTGAGAAGCCTACAGTGACTACAGTTTAT
GCCAACAATGGGTCTGTTCTCCAAGGAAGTTCTGTAGCCTCAGTGTATGATGGGAAGCTG
CTCATAGGCACTTTATACCACAGAGCCTTGTATTGTGAACTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 354 |
| Molecular Weight
| 39380.535 |
| Theoretical pI
| 5.599 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serum paraoxonase/arylesterase 2
MGAWVGCGLAGDRAGFLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN
GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI
DNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYAT
NDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADIL
AHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPS
SEVLRIQNILCEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL
|
| External Links |
|---|
| GenBank ID Protein
| 1333632 |
| UniProtKB/Swiss-Prot ID
| Q15165 |
| UniProtKB/Swiss-Prot Entry Name
| PON2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L48513 |
| GeneCard ID
| PON2 |
| GenAtlas ID
| PON2 |
| HGNC ID
| HGNC:9205 |
| References |
|---|
| General References
| Not Available |