Cannabis Compound Database: Showing Protein Serum paraoxonase/arylesterase 1 (CDBP00088)

Identification Biological properties Gene properties Protein properties External links References XML Show 7 compounds

Identification

HMDB Protein ID

CDBP00088

Secondary Accession Numbers

Not Available

Name

Serum paraoxonase/arylesterase 1

Description

Not Available

Synonyms

A-esterase 1
Aromatic esterase 1
K-45
PON 1
Serum aryldialkylphosphatase 1

Gene Name

PON1

Protein Type

Enzyme

Biological Properties

General Function

Involved in arylesterase activity

Specific Function

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

GO Classification

Biological Process
aromatic compound catabolic process
phosphatidylcholine metabolic process
carboxylic acid catabolic process
organophosphate catabolic process
positive regulation of binding
positive regulation of cholesterol efflux
response to external stimulus
response to toxin
positive regulation of transporter activity
Cellular Component
spherical high-density lipoprotein particle
Component
extracellular region
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
carboxylesterase activity
arylesterase activity
Molecular Function
phospholipid binding
protein homodimerization activity
calcium ion binding
aryldialkylphosphatase activity
arylesterase activity

Cellular Location

Secreted
extracellular space

Pathways

Name	SMPDB/Pathwhiz	KEGG
Clopidogrel Action Pathway		Not Available
Clopidogrel Metabolism Pathway		Not Available

Gene Properties

Chromosome Location

Locus

7q21.3

SNPs

PON1

Gene Sequence

>1068 bp
ATGGCGAAGCTGATTGCGCTCACCCTCTTGGGGATGGGACTGGCACTCTTCAGGAACCAC
CAGTCTTCTTACCAAACACGACTTAATGCTCTCCGAGAGGTACAACCCGTAGAACTTCCT
AACTGTAATTTAGTTAAAGGAATCGAAACTGGCTCTGAAGACTTGGAGATACTGCCTAAT
GGACTGGCTTTCATTAGCTCTGGATTAAAGTATCCTGGAATAAAGAGCTTCAACCCCAAC
AGTCCTGGAAAAATACTTCTGATGGACCTGAATGAAGAAGATCCAACAGTGTTGGAATTG
GGGATCACTGGAAGTAAATTTGATGTATCTTCATTTAACCCTCATGGGATTAGCACATTC
ACAGATGAAGATAATGCCATGTACCTCCTGGTGGTGAACCATCCAGATGCCAAGTCCACA
GTGGAGTTGTTTAAATTTCAAGAAGAAGAAAAATCGCTTTTGCATCTAAAAACCATCAGA
CATAAACTTCTGCCTAATTTGAATGATATTGTTGCTGTGGGACCTGAGCACTTTTATGGC
ACAAATGATCACTATTTTCTTGACCCCTACTTACAATCCTGGGAGATGTATTTGGGTTTA
GCGTGGTCGTATGTTGTCTACTATAGTCCAAGTGAAGTTCGAGTGGTGGCAGAAGGATTT
GATTTTGCTAATGGAATCAACATTTCACCCGATGGCAAGTATGTCTATATAGCTGAGTTG
CTGGCTCATAAGATTCATGTGTATGAAAAGCATGCTAATTGGACTTTAACTCCATTGAAG
TCCCTTGACTTTAATACCCTCGTGGATAACATATCTGTGGATCCTGAGACAGGAGACCTT
TGGGTTGGATGCCATCCCAATGGCATGAAAATCTTCTTCTATGACTCAGAGAATCCTCCT
GCATCAGAGGTGCTTCGAATCCAGAACATTCTAACAGAAGAACCTAAAGTGACACAGGTT
TATGCAGAAAATGGCACAGTGTTGCAAGGCAGTACAGTTGCCTCTGTGTACAAAGGGAAA
CTGCTGATTGGCACAGTGTTTCACAAAGCTCTTTACTGTGAGCTCTAA

Protein Properties

Number of Residues

355

Molecular Weight

39730.99

Theoretical pI

5.225

Pfam Domain Function

Arylesterase (PF01731 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Serum paraoxonase/arylesterase 1
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN
GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF
TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG
TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL
LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP
ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL

External Links

GenBank ID Protein

2795823

UniProtKB/Swiss-Prot ID

P27169

UniProtKB/Swiss-Prot Entry Name

PON1_HUMAN

PDB IDs