| Identification |
|---|
| HMDB Protein ID
| CDBP00080 |
| Secondary Accession Numbers
| Not Available |
| Name
| Thymidylate kinase |
| Description
| Not Available |
| Synonyms
|
- dTMP kinase
|
| Gene Name
| DTYMK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in thymidylate kinase activity |
| Specific Function
| Catalyzes the conversion of dTMP to dTDP.
|
| GO Classification
|
| Biological Process |
| cell cycle |
| dTDP biosynthetic process |
| dTTP biosynthetic process |
| nucleobase-containing small molecule interconversion |
| cell proliferation |
| cellular response to growth factor stimulus |
| Cellular Component |
| cytosol |
| Function |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| thymidylate kinase activity |
| binding |
| catalytic activity |
| phosphotransferase activity, phosphate group as acceptor |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| nucleoside binding |
| Molecular Function |
| nucleoside phosphate kinase activity |
| thymidylate kinase activity |
| ATP binding |
| Process |
| pyrimidine nucleotide biosynthetic process |
| pyrimidine nucleoside diphosphate biosynthetic process |
| pyrimidine deoxyribonucleoside diphosphate biosynthetic process |
| dtdp biosynthetic process |
| metabolic process |
| nitrogen compound metabolic process |
| cellular nitrogen compound metabolic process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| nucleobase, nucleoside and nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| nucleotide metabolic process |
| pyrimidine nucleotide metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | dTTP biosynthesis | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q37.3 |
| SNPs
| DTYMK |
| Gene Sequence
|
>636 bp
ATGGCGGCCCGGCGCGGGGCTCTCATAGTGCTGGAGGGCGTGGACCGCGCCGGGAAGAGC
ACGCAGAGCCGCAAGCTGGTGGAAGCGCTGTCGCGCGGGCCACCGCCCGAACTGCTCCGG
TTCCCGGAAAGATCAACTGAAATCGGCAAACTTCTGAGTTCCTACTTGCAAAAGAAAAGT
GACGTGGAGGATCACTCGGTGCACCTGCTTTTTTCTGCAAATCGCTGGGAACAAGTGCCG
TTAATTAAGGAAAAGTTGAGCCAGGGCGTGACCCTCGTCGTGGACAGATACGCATTTTCT
GGTGTGGCCTTCACCGGTGCCAAGGAGAATTTTTCCCTAGACTGGTGTAAACAGCCAGAC
GTGGGCCTTCCCAAACCCGACCTGGTCCTGTTCCTCCAGTTACAGCTGGCGGATGCTGCC
AAGCGGGGAGCGTTTGGCCATGAGCGCTATGAGAACGGGGCTTTCCAGGAGCGGGCGCTC
CGGTGTTTCCACCAGCTCATGAAAGACACGACTTTGAACTGGAAGATGGTGGATGCTTCC
AAAAGACTCGAAGCTGTCCATGAGGAACTCCGCGTGCTCTCTGAGGACGCCATCCGCACT
GCCACAGAGAAGCCGCTGGGGGAGCTATGGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 212 |
| Molecular Weight
| 23819.105 |
| Theoretical pI
| 8.267 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Thymidylate kinase
MAARRGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLQKK
SDVEDHSVHLLFSANRWEQVPLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCKQP
DVGLPKPDLVLFLQLQLADAAKRGAFGHERYENGAFQERALRCFHQLMKDTTLNWKMVDA
SKSIEAVHEDIRVLSEDAIRTATEKPLGELWK
|
| External Links |
|---|
| GenBank ID Protein
| 37206 |
| UniProtKB/Swiss-Prot ID
| P23919 |
| UniProtKB/Swiss-Prot Entry Name
| KTHY_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X54729 |
| GeneCard ID
| DTYMK |
| GenAtlas ID
| DTYMK |
| HGNC ID
| HGNC:3061 |
| References |
|---|
| General References
| Not Available |