Cannabis Compound Database: Showing Protein Dehydrogenase/reductase SDR family member 4 (CDBP00073)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00073

Secondary Accession Numbers

Not Available

Name

Dehydrogenase/reductase SDR family member 4

Description

Not Available

Synonyms

CR
NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
NADPH-dependent retinol dehydrogenase/reductase
NRDR
PHCR
PSCD
Peroxisomal short-chain alcohol dehydrogenase
SCAD-SRL
Short-chain dehydrogenase/reductase family member 4
humNRDR

Gene Name

DHRS4

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity

Specific Function

Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).

GO Classification

Biological Process
protein tetramerization
steroid metabolic process
cellular ketone metabolic process
oxidation-reduction process
alcohol metabolic process
Cellular Component
mitochondrion
nucleus
peroxisomal membrane
Function
oxidoreductase activity
binding
catalytic activity
Molecular Function
oxidoreductase activity
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
alcohol dehydrogenase [NAD(P)+] activity
carbonyl reductase (NADPH) activity
3-keto sterol reductase activity
nucleotide binding
Process
metabolic process
oxidation reduction

Cellular Location

Peroxisome

Pathways

Name	SMPDB/Pathwhiz	KEGG
Peroxisome	Not Available
Retinol Metabolism
Vitamin A Deficiency		Not Available

Gene Properties

Chromosome Location

Locus

14q11.2

SNPs

DHRS4

Gene Sequence

>837 bp
ATGCACAAGGCGGGGCTGCTAGGCCTCTGTGCCCGGGCTTGGAATTCGGTGCGGATGGCC
AGCTCCGGGATGACCCGCCGGGACCCGCTCGCAAATAAGGTGGCCCTGGTAACGGCCTCC
ACCGACGGGATCGGCTTCGCCATCGCCCGGCGTTTGGCCCAGGACGGGGCCCATGTGGTC
GTCAGCAGCCGGAAGCAGCAGAATGTGGACCAGGCGGTGGCCACGCTGCAGGGGGAGGGG
CTGAGCGTGACGGGCACCGTGTGCCATGTGGGGAAGGCGGAGGACCGGGAGCGGCTGGTG
GCCACGGCTGTGAAGCTTCATGGAGGTATCGATATCCTAGTCTCCAATGCTGCTGTCAAC
CCTTTCTTTGGAAGCATAATGGATGTCACTGAGGAGGTGTGGGACAAGACTCTGGACATT
AATGTGAAGGCCCCAGCCCTGATGACAAAGGCAGTGGTGCCAGAAATGGAGAAACGAGGA
GGCGGCTCAGTGGTGATCGTGTCTTCCATAGCAGCCTTCAGTCCATCTCCTGGCTTCAGT
CCTTACAATGTCAGTAAAACAGCCTTGCTGGGCCTGACCAAGACCCTGGCCATAGAGCTG
GCCCCAAGGAACATTAGGGTGAACTGCCTAGCACCTGGACTTATCAAGACTAGCTTCAGC
AGGATGCTCTGGATGGACAAGGAAAAAGAGGAAAGCATGAAAGAAACCCTGCGGATAAGA
AGGTTAGGCGAGCCAGAGGATTGTGCTGGCATCGTGTCTTTCCTGTGCTCTGAAGATGCC
AGCTACATCACTGGGGAAACAGTGGTGGTGGGTGGAGGAACCCCGTCCCGCCTCTGA

Protein Properties

Number of Residues

278

Molecular Weight

29536.885

Theoretical pI

8.555

Pfam Domain Function

adh_short (PF00106 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Dehydrogenase/reductase SDR family member 4
MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVV
VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVN
PFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS
PYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIR
RLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL

External Links

GenBank ID Protein

32483357

UniProtKB/Swiss-Prot ID

Q9BTZ2

UniProtKB/Swiss-Prot Entry Name

DHRS4_HUMAN

PDB IDs