Identification
HMDB Protein ID CDBP00073
Secondary Accession Numbers Not Available
Name Dehydrogenase/reductase SDR family member 4
Description Not Available
Synonyms
  1. CR
  2. NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
  3. NADPH-dependent retinol dehydrogenase/reductase
  4. NRDR
  5. PHCR
  6. PSCD
  7. Peroxisomal short-chain alcohol dehydrogenase
  8. SCAD-SRL
  9. Short-chain dehydrogenase/reductase family member 4
  10. humNRDR
Gene Name DHRS4
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
GO Classification
Biological Process
protein tetramerization
steroid metabolic process
cellular ketone metabolic process
oxidation-reduction process
alcohol metabolic process
Cellular Component
mitochondrion
nucleus
peroxisomal membrane
Function
oxidoreductase activity
binding
catalytic activity
Molecular Function
oxidoreductase activity
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
alcohol dehydrogenase [NAD(P)+] activity
carbonyl reductase (NADPH) activity
3-keto sterol reductase activity
nucleotide binding
Process
metabolic process
oxidation reduction
Cellular Location
  1. Peroxisome
Pathways
Gene Properties
Chromosome Location 14
Locus 14q11.2
SNPs DHRS4
Gene Sequence
>837 bp
ATGCACAAGGCGGGGCTGCTAGGCCTCTGTGCCCGGGCTTGGAATTCGGTGCGGATGGCC
AGCTCCGGGATGACCCGCCGGGACCCGCTCGCAAATAAGGTGGCCCTGGTAACGGCCTCC
ACCGACGGGATCGGCTTCGCCATCGCCCGGCGTTTGGCCCAGGACGGGGCCCATGTGGTC
GTCAGCAGCCGGAAGCAGCAGAATGTGGACCAGGCGGTGGCCACGCTGCAGGGGGAGGGG
CTGAGCGTGACGGGCACCGTGTGCCATGTGGGGAAGGCGGAGGACCGGGAGCGGCTGGTG
GCCACGGCTGTGAAGCTTCATGGAGGTATCGATATCCTAGTCTCCAATGCTGCTGTCAAC
CCTTTCTTTGGAAGCATAATGGATGTCACTGAGGAGGTGTGGGACAAGACTCTGGACATT
AATGTGAAGGCCCCAGCCCTGATGACAAAGGCAGTGGTGCCAGAAATGGAGAAACGAGGA
GGCGGCTCAGTGGTGATCGTGTCTTCCATAGCAGCCTTCAGTCCATCTCCTGGCTTCAGT
CCTTACAATGTCAGTAAAACAGCCTTGCTGGGCCTGACCAAGACCCTGGCCATAGAGCTG
GCCCCAAGGAACATTAGGGTGAACTGCCTAGCACCTGGACTTATCAAGACTAGCTTCAGC
AGGATGCTCTGGATGGACAAGGAAAAAGAGGAAAGCATGAAAGAAACCCTGCGGATAAGA
AGGTTAGGCGAGCCAGAGGATTGTGCTGGCATCGTGTCTTTCCTGTGCTCTGAAGATGCC
AGCTACATCACTGGGGAAACAGTGGTGGTGGGTGGAGGAACCCCGTCCCGCCTCTGA
Protein Properties
Number of Residues 278
Molecular Weight 29536.885
Theoretical pI 8.555
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Dehydrogenase/reductase SDR family member 4
MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVV
VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVN
PFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS
PYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIR
RLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL
GenBank ID Protein 32483357
UniProtKB/Swiss-Prot ID Q9BTZ2
UniProtKB/Swiss-Prot Entry Name DHRS4_HUMAN
PDB IDs
GenBank Gene ID NM_021004.2
GeneCard ID DHRS4
GenAtlas ID DHRS4
HGNC ID HGNC:16985
References
General References Not Available