Cannabis Compound Database: Showing Protein Carbonyl reductase [NADPH] 1 (CDBP00072)

Identification Biological properties Gene properties Protein properties External links References XML Show 7 compounds

Identification

HMDB Protein ID

CDBP00072

Secondary Accession Numbers

Not Available

Name

Carbonyl reductase [NADPH] 1

Description

Not Available

Synonyms

15-hydroxyprostaglandin dehydrogenase [NADP+]
NADPH-dependent carbonyl reductase 1
Prostaglandin 9-ketoreductase
Prostaglandin-E(2) 9-reductase
15-hydroxyprostaglandin dehydrogenase [NADP(+)]

Gene Name

CBR1

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity

Specific Function

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

GO Classification

Biological Process
drug metabolic process
vitamin K metabolic process
Cellular Component
cytoplasm
Function
binding
catalytic activity
oxidoreductase activity
Molecular Function
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
15-hydroxyprostaglandin dehydrogenase (NADP+) activity
carbonyl reductase (NADPH) activity
prostaglandin-E2 9-reductase activity
nucleotide binding
Process
metabolic process
oxidation reduction

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Metabolism of xenobiotics by cytochrome P450	Not Available
Chemical carcinogenesis	Not Available
Arachidonic Acid Metabolism
Leukotriene C4 Synthesis Deficiency		Not Available
Piroxicam Action Pathway		Not Available

Gene Properties

Chromosome Location

Locus

21q22.13

SNPs

CBR1

Gene Sequence

>834 bp
ATGTCGTCCGGCATCCATGTAGCGCTGGTGACTGGAGGCAACAAGGGCATCGGCTTGGCC
ATCGTGCGCGACCTGTGCCGGCTGTTCTCGGGGGACGTGGTGCTCACGGCGCGGGACGTG
ACGCGGGGCCAGGCGGCCGTACAGCAGCTGCAGGCGGAGGGCCTGAGCCCGCGCTTCCAC
CAGCTGGACATCGACGATCTGCAGAGCATCCGCGCCCTGCGCGACTTCCTGCGCAAGGAG
TACGGGGGCCTGGACGTGCTGGTCAACAACGCGGGCATCGCCTTCAAGGTTGCTGATCCC
ACACCCTTTCATATTCAAGCTGAAGTGACGATGAAAACAAATTTCTTTGGTACCCGAGAT
GTGTGCACAGAATTACTCCCTCTAATAAAACCCCAAGGGAGAGTGGTGAACGTATCTAGC
ATCATGAGCGTCAGAGCCCTTAAAAGCTGCAGCCCAGAGCTGCAGCAGAAGTTCCGCAGT
GAGACCATCACTGAGGAGGAGCTGGTGGGGCTCATGAACAAGTTTGTGGAGGATACAAAG
AAGGGAGTGCACCAGAAGGAGGGCTGGCCCAGCAGCGCATACGGGGTGACGAAGATTGGC
GTCACCGTTCTGTCCAGGATCCACGCCAGGAAACTGAGTGAGCAGAGGAAAGGGGACAAG
ATCCTCCTGAATGCCTGCTGCCCAGGGTGGGTGAGAACTGACATGGCGGGACCCAAGGCC
ACCAAGAGCCCAGAAGAAGGTGCAGAGACCCCTGTGTACTTGGCCCTTTTGCCCCCAGAT
GCTGAGGGTCCCCATGGACAATTTGTTTCAGAGAAGAGAGTTGAACAGTGGTGA

Protein Properties

Number of Residues

277

Molecular Weight

30374.73

Theoretical pI

8.319

Pfam Domain Function

adh_short (PF00106 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Carbonyl reductase [NADPH] 1
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P16152

UniProtKB/Swiss-Prot Entry Name

CBR1_HUMAN

PDB IDs