| Identification |
|---|
| HMDB Protein ID
| CDBP00002 |
| Secondary Accession Numbers
| Not Available |
| Name
| Deoxycytidylate deaminase |
| Description
| Not Available |
| Synonyms
|
- dCMP deaminase
|
| Gene Name
| DCTD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Supplies the nucleotide substrate for thymidylate synthetase.
|
| GO Classification
|
| Biological Process |
| pyrimidine nucleobase metabolic process |
| pyrimidine nucleotide metabolic process |
| nucleotide biosynthetic process |
| pyrimidine nucleoside biosynthetic process |
| Cellular Component |
| cytosol |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| transition metal ion binding |
| zinc ion binding |
| Molecular Function |
| dCMP deaminase activity |
| metal ion binding |
| zinc ion binding |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Pyrimidine Metabolism |    |  | | Beta Ureidopropionase Deficiency |    | Not Available | | UMP Synthase Deficiency (Orotic Aciduria) |    | Not Available | | Dihydropyrimidinase Deficiency |    | Not Available | | MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q35.1 |
| SNPs
| DCTD |
| Gene Sequence
|
>537 bp
ATGAGTGAAGTTTCCTGCAAGAAACGGGACGACTATTTGGAATGGCCAGAGTATTTTATG
GCTGTGGCCTTCTTATCAGCACAGAGAAGCAAAGATCCAAATTCCCAGGTCGGCGCCTGC
ATCGTGAATTCAGAAAACAAGATTGTCGGGATTGGGTACAATGGGATGCCAAATGGGTGC
AGTGATGACGTGTTGCCTTGGAGAAGGACAGCAGAGAATAAGCTGGACACCAAATACCCG
TACGTGTGCCATGCGGAGCTGAATGCCATCATGAACAAAAATTCGACCGATGTGAAAGGC
TGTAGTATGTATGTTGCCTTGTTCCCTTGTAATGAATGCGCTAAGCTCATCATCCAGGCA
GGTATAAAAGAAGTGATTTTCATGTCTGATAAATACCATGATAGTGACGAGGCAACTGCT
GCGAGGCTCCTGTTTAATATGGCCGGGGTGACATTCCGGAAATTCATACCGAAGTGCAGC
AAGATTGTCATTGACTTTGATTCAATTAACAGCAGACCGAGTCAAAAGCTTCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 178 |
| Molecular Weight
| 21013.96 |
| Theoretical pI
| 7.526 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Deoxycytidylate deaminase
MSEVSCKKRDDYLEWPEYFMAVAFLSAQRSKDPNSQVGACIVNSENKIVGIGYNGMPNGC
SDDVLPWRRTAENKLDTKYPYVCHAELNAIMNKNSTDVKGCSMYVALFPCNECAKLIIQA
GIKEVIFMSDKYHDSDEATAARLLFNMAGVTFRKFIPKCSKIVIDFDSINSRPSQKLQ
|
| External Links |
|---|
| GenBank ID Protein
| 61742819 |
| UniProtKB/Swiss-Prot ID
| P32321 |
| UniProtKB/Swiss-Prot Entry Name
| DCTD_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001921.2 |
| GeneCard ID
| DCTD |
| GenAtlas ID
| DCTD |
| HGNC ID
| HGNC:2710 |
| References |
|---|
| General References
| Not Available |