1.02020-04-17 18:41:34 UTC2020-12-07 19:11:03 UTCCDB004834ThymidineThymidine, also known as deoxythymidine or DTHD, belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleosides. Pyrimidine 2'-deoxyribonucleosides are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 2. Thymidine is an extremely weak basic (essentially neutral) compound (based on its pKa). Thymidine exists in all living species, ranging from bacteria to humans. In cell biology it is used to synchronize the cells in S phase. Within humans, thymidine participates in a number of enzymatic reactions. In particular, thymidine can be biosynthesized from 5-thymidylic acid through its interaction with the enzyme cytosolic purine 5'-nucleotidase. In addition, thymidine can be converted into 5-thymidylic acid; which is catalyzed by the enzyme thymidine kinase, cytosolic. In humans, thymidine is involved in the metabolic disorder called ump synthase deficiency (orotic aciduria). Outside of the human body, Thymidine has been detected, but not quantified in, several different foods, such as horned melons, asian pears, brassicas, japanese chestnuts, and apricots. This could make thymidine a potential biomarker for the consumption of these foods. Thymidine is a potentially toxic compound. Thymidine is non-toxic and is a naturally occurring compound that exists in all living organisms and DNA viruses. RNA does not have thymidine and has uridine instead. Thymidine is the DNA base T, which pairs with adenosine in double stranded DNA. 25% of DNA is composed of thymidine. Thymidine is a chemical compound which is a pyrimidine nucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. Thymidine is a pyrimidine deoxynucleoside. Thymidine is expected to be in Cannabis as all living plants are known to produce and metabolize it.1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione2'-Deoxy-5-methyluridine2'-Deoxythymidine2'-Thymidine5-Methyl-2'-deoxyuridineDeoxythymidineDTHDTThymine 2'-deoxyriboside1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione1-(2-Deoxy-beta-delta-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione1-[4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione2'-Deoxy-5-methyl-uridine5-MethyldeoxyuridineDeoxyribothymidineDTDThydThymidinThymine 2-desoxyribosideThymine deoxyribosideThymine-1 2-deoxy-b-D-ribofuranosideThymine-1 2-deoxy-beta-delta-ribofuranoside2' DeoxythymidineC10H14N2O5242.23242.09031-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dionethymidine50-89-5CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=OInChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1IQFYYKKMVGJFEH-XLPZGREQSA-N belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleosides. Pyrimidine 2'-deoxyribonucleosides are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 2.Pyrimidine 2'-deoxyribonucleosidesOrganic compoundsNucleosides, nucleotides, and analoguesPyrimidine nucleosidesPyrimidine 2'-deoxyribonucleosidesAromatic heteromonocyclic compoundsAzacyclic compoundsHeteroaromatic compoundsHydrocarbon derivativesHydropyrimidinesHydroxypyrimidinesOrganic oxidesOrganonitrogen compoundsOrganopnictogen compoundsOxacyclic compoundsPrimary alcoholsPyrimidonesSecondary alcoholsTetrahydrofuransAlcoholAromatic heteromonocyclic compoundAzacycleHeteroaromatic compoundHydrocarbon derivativeHydropyrimidineHydroxypyrimidineOrganic nitrogen compoundOrganic oxideOrganic oxygen compoundOrganoheterocyclic compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundOxacyclePrimary alcoholPyrimidinePyrimidine 2'-deoxyribonucleosidePyrimidoneSecondary alcoholTetrahydrofuranDeoxyribonucleosidespyrimidine 2'-deoxyribonucleosidewater_solubility73.5 mg/mLlogp-0.93logp-1.32logs-0.56logp-1.1pka_strongest_acidic9.96pka_strongest_basic-3iupac1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dioneaverage_mass242.23mono_mass242.0903smilesCC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=OformulaC10H14N2O5inchiInChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1inchikeyIQFYYKKMVGJFEH-XLPZGREQSA-Npolar_surface_area99.1refractivity55.41polarizability23.06rotatable_bond_count2acceptor_count5donor_count3physiological_charge0formal_charge0number_of_rings2bioavailability1rule_of_fiveYesghose_filterYesveber_ruleYesmddr_like_ruleYesC00214FDB0312015585DB04485578917748C00019698THYMIDINE50348Thymidine3375