1.02020-04-17 18:37:51 UTC2020-11-18 16:38:42 UTCCDB004798DeoxyguanosineDeoxyguanosine, also known as dG, belongs to the class of organic compounds known as purine 2'-deoxyribonucleosides. Purine 2'-deoxyribonucleosides are compounds consisting of a purine linked to a ribose which lacks a hydroxyl group at position 2. Deoxyguanosine is a nucleoside consisting of the base guanine and the sugar deoxyribose. Deoxyguanosine is an extremely weak basic (essentially neutral) compound (based on its pKa). Deoxyguanosine exists in all living species, ranging from bacteria to humans. Within humans, deoxyguanosine participates in a number of enzymatic reactions. In particular, deoxyguanosine can be biosynthesized from 2'-deoxyguanosine 5'-monophosphate; which is catalyzed by the enzyme cytosolic purine 5'-nucleotidase. In addition, deoxyguanosine can be converted into 2'-deoxyguanosine 5'-monophosphate; which is mediated by the enzyme deoxyguanosine kinase. In humans, deoxyguanosine is involved in the metabolic disorder called the purine nucleoside phosphorylase deficiency pathway. It is like guanosine, but with one oxygen atom removed. 8-OHDeoxyguanosine is a sensitive marker of the DNA damage This damage, if left unrepaired, has been proposed to contribute to mutagenicity and cancer promotion. Deoxyguanosine can be converted to 8-hydroxy-deoxyguanosine (8-OHdG) due to hydroxyl radical attack at the C8 of guanine. It is a nucleoside component of DNA. Deoxyguanosine is expected to be in Cannabis as all living plants are known to produce and metabolize it.2-Amino-9-(2-deoxy-9-beta-D-ribofuranosyl)-9H-purin-6-ol9-(2-Deoxy-beta-D-erythro-pentofuranosyl)-guaninedGGuanine deoxy nucleoside2'-Deoxyguanosine2-Amino-9-(2-deoxy-9-b-D-ribofuranosyl)-9H-purin-6-ol2-Amino-9-(2-deoxy-9-β-D-ribofuranosyl)-9H-purin-6-ol9-(2-Deoxy-b-D-erythro-pentofuranosyl)-guanine9-(2-Deoxy-β-D-erythro-pentofuranosyl)-guanine2'-Deoxy-guanosine2-Deoxyguanosine9-(2-Deoxy-b-D-erythro-pentofuranosyl)guanine9-(2-Deoxy-beta-delta-erythro-pentofuranosyl)-guanine9-(2-Deoxy-beta-delta-erythro-pentofuranosyl)guanineDesoxyguanosineGuanine deoxyribosideDeoxyguanosineC10H13N5O4267.24267.09682-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one2-deoxyguanosine961-07-9NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)N1InChI=1S/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/m0/s1YKBGVTZYEHREMT-KVQBGUIXSA-N belongs to the class of organic compounds known as purine 2'-deoxyribonucleosides. Purine 2'-deoxyribonucleosides are compounds consisting of a purine linked to a ribose which lacks a hydroxyl group at position 2.Purine 2'-deoxyribonucleosidesOrganic compoundsNucleosides, nucleotides, and analoguesPurine nucleosidesPurine 2'-deoxyribonucleosidesAromatic heteropolycyclic compounds6-oxopurinesAminopyrimidines and derivativesAzacyclic compoundsHeteroaromatic compoundsHydrocarbon derivativesHypoxanthinesN-substituted imidazolesOrganic oxidesOrganopnictogen compoundsOxacyclic compoundsPrimary alcoholsPrimary aminesPyrimidonesSecondary alcoholsTetrahydrofuransVinylogous amides6-oxopurineAlcoholAmineAminopyrimidineAromatic heteropolycyclic compoundAzacycleAzoleHeteroaromatic compoundHydrocarbon derivativeHypoxanthineImidazoleImidazopyrimidineN-substituted imidazoleOrganic nitrogen compoundOrganic oxideOrganic oxygen compoundOrganoheterocyclic compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundOxacyclePrimary alcoholPrimary aminePurinePurine 2'-deoxyribonucleosidePurinonePyrimidinePyrimidoneSecondary alcoholTetrahydrofuranVinylogous amideDeoxyribonucleosidespurine 2'-deoxyribonucleosidelogp-1.30melting_point300 °Clogp-1.75logs-1.37logp-1.8pka_strongest_acidic10.16pka_strongest_basic0.46iupac2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-oneaverage_mass267.24mono_mass267.0968smilesNC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)N1formulaC10H13N5O4inchiInChI=1S/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/m0/s1inchikeyYKBGVTZYEHREMT-KVQBGUIXSA-Npolar_surface_area134.99refractivity63.11polarizability25.24rotatable_bond_count2acceptor_count7donor_count4physiological_charge0formal_charge0number_of_rings3bioavailability1rule_of_fiveYesghose_filterYesveber_ruleYesmddr_like_ruleYesC00330187790163230FDB01206417172DEOXYGUANOSINE34637Deoxyguanosine3395