Showing Compound Card for Hydrazine (CDB000616)

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Record Information
Version1.0
Created at2020-03-19 00:46:50 UTC
Updated at2020-12-07 19:07:35 UTC
CannabisDB IDCDB000616
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameHydrazine
DescriptionHydrazine is an inorganic chemical compound with the formula N2H4. It is a colourless liquid with an ammonia-like odor and it is derived from the same industrial chemical processes used to manufacture ammonia. However, hydrazine has physical properties that are more similar to those of water. Direct alkylation of hydrazines with alkyl halides in the presence of base affords alkyl-substituted hydrazines, but the reaction is typically inefficient due to poor control on level of substitution (same as in ordinary amines). The reduction of hydrazones to hydrazines presents a clean path for the production of 1,1-dialkylated hydrazines. Being bifunctional, with two amines, hydrazine is a key building block for the preparation of many heterocyclic compounds via condensation with a range of difunctional electrophiles. With 2,4-pentanedione, it condenses to give the 3,5-dimethylpyrazole. In the Einhorn-Brunner reaction, hydrazines react with imides to give triazoles. Hydrazine is a convenient reductant because the by-products are typically nitrogen gas and water. Thus, it is used as an antioxidant, an oxygen scavenger, and a corrosion inhibitor in water boilers and heating systems. It is also used to reduce metal salts and oxides to the pure metals in electroless nickel plating and plutonium extraction from nuclear reactor waste. Hidrazine has been reported to occur naturally in tabaco and it was detected in the smoke of cigarettes (PMID: 4840592 ). Hydrazine has also been reported as a volatile component of cannabis samples seized by police (PMID: 26657499 ).
Structure
Thumb
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Synonyms
Chemical FormulaH4N2
Average Molecular Weight32.05
Monoisotopic Molecular Weight32.0374
IUPAC Namehydrazine
Traditional Namehydrazine
CAS Registry Number302-01-2
SMILES
NN
InChI Identifier
InChI=1S/H4N2/c1-2/h1-2H2
InChI KeyOAKJQQAXSVQMHS-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassHomogeneous other non-metal compounds
Sub ClassNot Available
Direct ParentHomogeneous other non-metal compounds
Alternative Parents
Substituents
  • Homogeneous other non metal
  • Hydrazine derivative
Molecular FrameworkNot Available
External Descriptors
Ontology
Physiological effect

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Role

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Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point2 °CNot Available
Boiling Point114 °CWikipedia
Water Solubility1000 mg/mLNot Available
logP-2.07HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Basic)5.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area52.04 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity10.57 m³·mol⁻¹ChemAxon
Polarizability3.25 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSHydrazine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-001i-9000000000-7e6c9f4fe38a72218c48Spectrum
Predicted GC-MSHydrazine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSHydrazine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
NMRNot Available
Pathways
Pathways
Protein Targets
EnzymesNot Available
TransportersNot Available
Metal BindingsNot Available
ReceptorsNot Available
Transcriptional FactorsNot Available
Concentrations Data
Not Available
HMDB IDHMDB0012973
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB013394
KNApSAcK IDNot Available
Chemspider ID8960
KEGG Compound IDC05361
BioCyc ID4-HYDROXYMETHYLPHENYLHYDRAZINE
BiGG IDNot Available
Wikipedia LinkHydrazine
METLIN IDNot Available
PubChem Compound9321
PDB IDNot Available
ChEBI ID15571
References
General References
  1. Liu YY, Schmeltz I, Hoffmann D: Chemical studies on tobacco smoke. Quantitative analysis of hydrazine in tobacco and cigarette smoke. Anal Chem. 1974 Jun;46(7):885-9. doi: 10.1021/ac60343a046. [PubMed:4840592 ]
  2. Rice S, Koziel JA: Characterizing the Smell of Marijuana by Odor Impact of Volatile Compounds: An Application of Simultaneous Chemical and Sensory Analysis. PLoS One. 2015 Dec 10;10(12):e0144160. doi: 10.1371/journal.pone.0144160. eCollection 2015. [PubMed:26657499 ]