Cannabis Compound Database: Showing Compound Card for L-Valine (CDB000136)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (6)transporters (1) Show 8 proteins XML

Record Information

Version

1.0

Created at

2020-03-18 23:26:07 UTC

Updated at

2022-12-13 23:36:22 UTC

CannabisDB ID

CDB000136

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

L-Valine

Description

Valine, abbreviated as Val or V, one of 20 proteinogenic amino acids, is a non-polar amino acid with the chemical formula HO2CCH(NH2)CH(CH3)2. Valine is an essential amino acid that humans do not synthesize and must acquire from diet, usually from protein sources. Along with leucine and isoleucine, valine is a branched-chain amino acid (BCAA), an amino acid whose carbon structure is marked by a branch point. These three amino acids are critical to human life and are particularly involved in stress, energy and muscle metabolism. BCAA supplementation as therapy, both oral and intravenous, in human health and disease holds great promise. Despite their structural similarities, the branched amino acids have different metabolic routes, with valine going solely to carbohydrates, leucine solely to fats and isoleucine to both. The different metabolism accounts for different requirements for these essential amino acids in humans: 12 mg/kg, 14 mg/kg and 16 mg/kg of valine, leucine, and isoleucine, respectively. Furthermore, these amino acids have different deficiency symptoms. Valine deficiency is marked by neurological defects in the brain, while isoleucine deficiency is marked by muscle tremors. Many types of inborn errors of BCAA metabolism exist and are marked by various abnormalities. The most common form is the maple syrup urine disease, marked by a sweet urinary odor. Other abnormalities are associated with a wide range of symptoms, such as mental retardation, ataxia, hypoglycemia, spinal muscle atrophy, rash, vomiting and excessive muscle movement. Most forms of BCAA metabolism errors are corrected by dietary restriction of BCAA and at least one form is correctable by supplementation with 10 mg of biotin daily. BCAA are decreased in patients with liver disease, such as hepatitis, hepatic coma, cirrhosis, extrahepatic biliary atresia or portacaval shunt; aromatic amino acids (AAA) tyrosine, tryptophan and phenylalanine, as well as methionine are increased in these conditions. Valine has been established as a useful supplemental therapy for an ailing liver. All the BCAA probably compete with AAA for absorption into the brain. Supplemental BCAA with vitamin B6 and zinc help normalize the BCAA:AAA ratio. In sickle-cell disease, the hydrophobic amino acid valine replaces the hydrophilic amino acid glutamic acid in beta-globin, causing it to misfold. The sickle cell hemoglobin is thus prone to aggregation. Hypervalinemia is another example of an inborn error of metabolism involving valine, not the other BCAA. It is caused by a deficiency in the valine transaminase gene (PMID: 6067402 ). As with most amino acids, L-valine is also found in Cannabis plants (PMID: 6991645 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2S)-2-Amino-3-methylbutanoic acid	ChEBI
(S)-Valine	ChEBI
2-Amino-3-methylbutyric acid	ChEBI
L-(+)-alpha-Aminoisovaleric acid	ChEBI
L-alpha-Amino-beta-methylbutyric acid	ChEBI
L-Valin	ChEBI
V	ChEBI
Val	ChEBI
VALINE	ChEBI
(2S)-2-Amino-3-methylbutanoate	Generator
2-Amino-3-methylbutyrate	Generator
L-(+)-a-Aminoisovalerate	Generator
L-(+)-a-Aminoisovaleric acid	Generator
L-(+)-alpha-Aminoisovalerate	Generator
L-(+)-Α-aminoisovalerate	Generator
L-(+)-Α-aminoisovaleric acid	Generator
L-a-Amino-b-methylbutyrate	Generator
L-a-Amino-b-methylbutyric acid	Generator
L-alpha-Amino-beta-methylbutyrate	Generator
L-Α-amino-β-methylbutyrate	Generator
L-Α-amino-β-methylbutyric acid	Generator
(S)-2-Amino-3-methyl-butanoate	HMDB
(S)-2-Amino-3-methyl-butanoic acid	HMDB
(S)-2-Amino-3-methylbutanoate	HMDB
(S)-2-Amino-3-methylbutanoic acid	HMDB
(S)-2-Amino-3-methylbutyrate	HMDB
(S)-2-Amino-3-methylbutyric acid	HMDB
(S)-a-Amino-b-methylbutyrate	HMDB
(S)-a-Amino-b-methylbutyric acid	HMDB
(S)-alpha-Amino-beta-methylbutyrate	HMDB
(S)-alpha-Amino-beta-methylbutyric acid	HMDB
2-Amino-3-methylbutanoate	HMDB
2-Amino-3-methylbutanoic acid	HMDB
L Valine	HMDB

Chemical Formula

C₅H₁₁NO₂

Average Molecular Weight

117.15

Monoisotopic Molecular Weight

117.079

IUPAC Name

(2S)-2-amino-3-methylbutanoic acid

Traditional Name

L-valine

CAS Registry Number

72-18-4

SMILES

CC(C)[C@H](N)C(O)=O

InChI Identifier

InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1

InChI Key

KZSNJWFQEVHDMF-BYPYZUCNSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as valine and derivatives. Valine and derivatives are compounds containing valine or a derivative thereof resulting from reaction of valine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Valine and derivatives

Alternative Parents

Substituents

Valine or derivatives
Alpha-amino acid
L-alpha-amino acid
Branched fatty acid
Methyl-branched fatty acid
Fatty acid
Fatty acyl
Amino acid
Monocarboxylic acid or derivatives
Carboxylic acid
Organic oxide
Organopnictogen compound
Primary amine
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Carbonyl group
Organic oxygen compound
Amine
Organic nitrogen compound
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:16414 )
L-alpha-amino acid (CHEBI:16414 )
valine (CHEBI:16414 )
pyruvate family amino acid (CHEBI:16414 )
Common amino acids (C00183 )

Ontology

Metabolism and nutrition disorders:

Hypoglycemia

Ingestion

Source:

Food

Synthetic:

Personal care product

Biological:

Animal

Plant:

Biological location:

Tissue and substructures:

Biofluid and excreta:

Cell and elements:

Extracellular

Cell:

Fibroblast

Subcellular:

Role

Industrial application:

Personal care products

Food and nutrition:

Nutritional supplement

Pharmaceutical industry:

Pharmaceutical

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	295 - 300 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	58.5 mg/mL	Not Available
logP	-2.26	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-2.3	ALOGPS
logP	-2	ChemAxon
logS	0.26	ALOGPS
pKa (Strongest Acidic)	2.72	ChemAxon
pKa (Strongest Basic)	9.6	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	63.32 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	29.49 m³·mol⁻¹	ChemAxon
Polarizability	12.19 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-05fr-9000000000-5d10fb7acd70b2f43368	2018-05-25	View Spectrum
GC-MS	L-Valine, 2 TMS, GC-MS Spectrum	splash10-0006-0910000000-23bfcf2795f71f458bda	Spectrum
GC-MS	L-Valine, 2 TMS, GC-MS Spectrum	splash10-0006-0920000000-7892bb9d4d9afcc23410	Spectrum
GC-MS	L-Valine, 2 TMS, GC-MS Spectrum	splash10-0006-0910000000-f2491152816b9c5dc7ed	Spectrum
GC-MS	L-Valine, 1 TMS, GC-MS Spectrum	splash10-0znj-1900000000-7c976d7c11a402db399f	Spectrum
GC-MS	L-Valine, 2 TMS, GC-MS Spectrum	splash10-00dl-8910000000-78e8ee971ad7298c23cd	Spectrum
GC-MS	L-Valine, 1 TMS, GC-MS Spectrum	splash10-00di-9200000000-805e6724e5181af78c81	Spectrum
GC-MS	L-Valine, 2 TMS, GC-MS Spectrum	splash10-0006-0910000000-a212771a5ea868139d5a	Spectrum
GC-MS	L-Valine, non-derivatized, GC-MS Spectrum	splash10-059t-0900000000-7b8e4e98ac9158bf26d9	Spectrum
GC-MS	L-Valine, non-derivatized, GC-MS Spectrum	splash10-0006-0910000000-9079324093be9a14d47a	Spectrum
GC-MS	L-Valine, non-derivatized, GC-MS Spectrum	splash10-0006-0910000000-23bfcf2795f71f458bda	Spectrum
GC-MS	L-Valine, non-derivatized, GC-MS Spectrum	splash10-0006-0920000000-7892bb9d4d9afcc23410	Spectrum
GC-MS	L-Valine, non-derivatized, GC-MS Spectrum	splash10-0006-0910000000-f2491152816b9c5dc7ed	Spectrum
GC-MS	L-Valine, non-derivatized, GC-MS Spectrum	splash10-0znj-1900000000-7c976d7c11a402db399f	Spectrum
GC-MS	L-Valine, non-derivatized, GC-MS Spectrum	splash10-000i-2920000000-1628d46d5520c5f20de8	Spectrum
GC-MS	L-Valine, non-derivatized, GC-MS Spectrum	splash10-00dl-8910000000-78e8ee971ad7298c23cd	Spectrum
GC-MS	L-Valine, non-derivatized, GC-MS Spectrum	splash10-00di-9200000000-805e6724e5181af78c81	Spectrum
GC-MS	L-Valine, non-derivatized, GC-MS Spectrum	splash10-0006-0910000000-a212771a5ea868139d5a	Spectrum
Predicted GC-MS	L-Valine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00dl-9000000000-602d1e01bc7567493e4c	Spectrum
Predicted GC-MS	L-Valine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00dl-9500000000-a758682a7aafbd0d553e	Spectrum
Predicted GC-MS	L-Valine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Valine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Valine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Valine, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Valine, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-00di-9000000000-67498a3295a1fe788c4b	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0a4i-9000000000-fb359f44fcf1b83ee14d	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0a4i-9000000000-8e5f620c04615765a062	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014r-0900000000-619d80cc41221405e0bd	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-9000000000-17ab53cec2e6b727c3e9	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-9000000000-0dfbcc85d6423af91eda	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014l-4900000000-c50d79ba3a5013bcf29f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0uxr-0900000000-67a7784963ec75cecaa0	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-9000000000-4569516f23d8a712b434	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-d928cac1226f19b8edc3	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-0900000000-34059351f2cbd94a8acc	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-014i-0900000000-a36d8d68a6705027415f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-014i-0900000000-1a5d8f4c1b293de18fed	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-014i-0900000000-b410df2c18dfc8ab7165	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0gi0-6900000000-c87ff036e3a5d15b7670	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-00di-9000000000-561b3b28fa82e0b10658	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-05fr-9000000000-11e7c0a3d5cf8e4dedfe	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-0a4i-9000000000-6a6f8cd9629b0f09469c	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-0a4i-9000000000-4518f691bbda5739c0f1	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - CE-ESI-TOF (CE-system connected to 6210 Time-of-Flight MS, Agilent) , Positive	splash10-014i-0900000000-a931cfc8207edac33775	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-00di-9000000000-430332b13b8c6368136b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-014i-0900000000-ffb286a8ae38a0a3e6d2	2012-08-31	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00xr-9500000000-bb54662a5fd1dd142d90	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-00di-9000000000-1f7d9c10db4226a383c1	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-05fu-9000000000-f6d7e45bb3f3436e5eb7	2016-09-12	View Spectrum

NMR

Type	Description	View
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Valine, Leucine and Isoleucine Degradation
Propanoate Metabolism
Transcription/Translation	Not Available	Not Available
Beta-Ketothiolase Deficiency		Not Available
2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	3q21-q22	P05166	details
Catechol O-methyltransferase	COMT	22q11.21	P21964	details
Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	12p12.1	P54687	details
Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	19q13	O15382	details
Valine--tRNA ligase	VARS	6p21.3	P26640	details
Valine--tRNA ligase, mitochondrial	VARS2	6p21.33	Q5ST30	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Monocarboxylate transporter 10	SLC16A10	6q21-q22	Q8TF71	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Catechol O-methyltransferase	COMT	22q11.21	P21964	details

Receptors

Not Available

Transcriptional Factors

Not Available

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	0.537 mg/g dry wt	David S. Wishart,...	details
Gabriola	Detected and Quantified	0.334 mg/g dry wt	David S. Wishart,...	details
Island Honey	Detected and Quantified	0.422 mg/g dry wt	David S. Wishart,...	details
Quadra	Detected and Quantified	0.439 mg/g dry wt	David S. Wishart,...	details
Sensi Star	Detected and Quantified	0.198 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	0.172 mg/g dry wt	David S. Wishart,...	details

External Links

HMDB ID

HMDB0000883

DrugBank ID

DB00161

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

16414

References

General References

Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]
Dancis J, Hutzler J, Tada K, Wada Y, Morikawa T, Arakawa T: Hypervalinemia. A defect in valine transamination. Pediatrics. 1967 Jun;39(6):813-7. [PubMed:6067402 ]

Enzymes

Enzyme Details

1. Propionyl-CoA carboxylase beta chain, mitochondrial

General function:: Involved in ligase activity
Specific function:: Not Available
Gene Name:: PCCB
Uniprot ID:: P05166
Molecular weight:: 58215.13

Enzyme Details

2. Catechol O-methyltransferase

General function:: Involved in magnesium ion binding
Specific function:: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Gene Name:: COMT
Uniprot ID:: P21964
Molecular weight:: 30036.77

Enzyme Details

3. Branched-chain-amino-acid aminotransferase, cytosolic

General function:: Involved in catalytic activity
Specific function:: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Gene Name:: BCAT1
Uniprot ID:: P54687
Molecular weight:: 38644.77

Enzyme Details

4. Branched-chain-amino-acid aminotransferase, mitochondrial

General function:: Involved in catalytic activity
Specific function:: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
Gene Name:: BCAT2
Uniprot ID:: O15382
Molecular weight:: 33776.315

Enzyme Details

5. Valine--tRNA ligase

General function:: Involved in nucleotide binding
Specific function:: Not Available
Gene Name:: VARS
Uniprot ID:: P26640
Molecular weight:: 140474.755

Enzyme Details

6. Valine--tRNA ligase, mitochondrial

General function:: Involved in nucleotide binding
Specific function:: Not Available
Gene Name:: VARS2
Uniprot ID:: Q5ST30
Molecular weight:: 102414.65

Transporters

Enzyme Details

1. Monocarboxylate transporter 10

General function:: Involved in transmembrane transport
Specific function:: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:: SLC16A10
Uniprot ID:: Q8TF71
Molecular weight:: 55492.1

Showing Compound Card for L-Valine (CDB000136)

Structure for CDB000136 (L-Valine)

Enzymes

Transporters