Cannabis Compound Database: Showing Compound Card for Piperidine (CDB000075)

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Record Information

Version

1.0

Created at

2020-03-18 23:23:50 UTC

Updated at

2021-01-04 20:37:38 UTC

CannabisDB ID

CDB000075

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Piperidine

Description

Piperidine, (CH2)5NH, also known as azacyclohexane or hexahydropyridine, is named after the genus Piper, which is Latin for pepper. It belongs to the class of organic compounds known as piperidines. Piperidines are compounds containing a piperidine ring, which is a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms. Piperidine is a strong basic compound that is soluble in water and alcohol. It is a colorless fuming liquid with a sweet, floral, and animal-like odor. It is found in black pepper fruit, oil and seed (Piper nigrum), barley seeds, celery plant, bell peppers, soybean seed and tobacco ( Ref:DOI ). Piperidine is a flavor and flavouring agent. Piperidine is also a constituent of cannabis smoke. It is volatilized during the combustion of cannabis ( Ref:DOI ). In addition to cannabis plants (PMID: 6991645 ), piperidine was obtained from the plants¬†Psilocaulon absimile¬†(Aizoaceae) and in¬†Petrosimonia monandra ( Ref:DOI ). Piperidine is metabolized by microbes and is potentially used as an anti-bacterial agent controlling bacterial populations within rhizomes (http//doi.org/10.1101/499731). Piperidine is a widely used building block and chemical reagent in the synthesis of organic compounds, including pharmaceuticals such as vasodilators and antipsychotic medications (PMID¬†25255204). Piperidine is a widely used secondary amine and used to convert ketones to enamines. Enamines derived from piperidine can be used in the Stork enamine alkylation reaction. Piperidine is used as a solvent and as a base. The same is true for certain derivatives: N-formylpiperidine is a polar aprotic solvent with better hydrocarbon solubility than other amide solvents, and 2,2,6,6-tetramethylpiperidine is highly sterically hindered base, useful because of its low nucleophilicity and high solubility in organic solvents.

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Value	Source
Azacyclohexane	ChEBI
Azinane	ChEBI
Cyclopentimine	ChEBI
Cypentil	ChEBI
Hexahydropyridine	ChEBI
Hexazane	ChEBI
Pentamethyleneamine	ChEBI
Pentamethyleneimine	ChEBI
Pentamethylenimine	ChEBI
Perhydropyridine	ChEBI
pip	ChEBI
Piperidin	ChEBI
FEMA 2908	HMDB
hexahydro-Pyridine	HMDB
Piperidine ON rasta resin	HMDB

Chemical Formula

C₅H₁₁N

Average Molecular Weight

85.15

Monoisotopic Molecular Weight

85.0891

IUPAC Name

piperidine

Traditional Name

piperidine

CAS Registry Number

110-89-4

SMILES

C1CCNCC1

InChI Identifier

InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2

InChI Key

NQRYJNQNLNOLGT-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as piperidines. Piperidines are compounds containing a piperidine ring, which is a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Piperidines

Sub Class

Not Available

Direct Parent

Piperidines

Alternative Parents

Substituents

Piperidine
Azacycle
Secondary amine
Secondary aliphatic amine
Organic nitrogen compound
Organopnictogen compound
Hydrocarbon derivative
Organonitrogen compound
Amine
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

piperidines (CHEBI:18049 )
secondary amine (CHEBI:18049 )
azacycloalkane (CHEBI:18049 )
saturated organic heteromonocyclic parent (CHEBI:18049 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Food

Biological:

Microbe

Plant:

Biological location:

Biofluid and excreta:

Subcellular:

Cytoplasm

Cell and elements:

Extracellular

Role

Industrial application:

Laboratory chemical

Household products:

Antimicrobial agent:

Antibacterial

Food and nutrition:

Flavoring agent

Biological role:

Nutrient

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	-9 °C	Not Available
Boiling Point	106 °C	Wikipedia
Water Solubility	1000 mg/mL at 20 °C	Not Available
logP	0.84	Not Available

Predicted Properties

Property	Value	Source
logP	0.97	ALOGPS
logP	0.66	ChemAxon
logS	0.16	ALOGPS
pKa (Strongest Basic)	10.4	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	12.03 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	26.84 m³·mol⁻¹	ChemAxon
Polarizability	10.43 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-053u-9000000000-9b296a6ad56d186eee6f	2015-03-01	View Spectrum
GC-MS	Piperidine, non-derivatized, GC-MS Spectrum	splash10-0543-9000000000-6b1887859e5474352d6e	Spectrum
GC-MS	Piperidine, non-derivatized, GC-MS Spectrum	splash10-053u-9000000000-507e3f9eabf271f642f3	Spectrum
GC-MS	Piperidine, non-derivatized, GC-MS Spectrum	splash10-0563-9000000000-c08d3d67e81c397678d2	Spectrum
GC-MS	Piperidine, non-derivatized, GC-MS Spectrum	splash10-0543-9000000000-6b1887859e5474352d6e	Spectrum
GC-MS	Piperidine, non-derivatized, GC-MS Spectrum	splash10-053u-9000000000-507e3f9eabf271f642f3	Spectrum
GC-MS	Piperidine, non-derivatized, GC-MS Spectrum	splash10-0563-9000000000-c08d3d67e81c397678d2	Spectrum
Predicted GC-MS	Piperidine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-052u-9000000000-95f068cd42017a2e7446	Spectrum
Predicted GC-MS	Piperidine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Piperidine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-000i-9000000000-a76c8bf8d69f5f3e831a	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-000i-9000000000-fe1ffe6a62bbbfa35a46	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-000i-9000000000-c57e3de57c466c728f49	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-000f-9000000000-7936721ae1a323f2cd83	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-000f-9000000000-6bcb90141de97851b0ce	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-000i-9000000000-155786c0621c522e75a7	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-014i-9000000000-646cb2a227fa351da3dc	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-014i-9000000000-32222dc7a0d132edf443	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-014i-9000000000-646cb2a227fa351da3dc	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-014i-9000000000-071a5573608ae27993d5	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-014i-9000000000-80fe3a58dda39ff48e6f	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-000i-9000000000-544d5b027d322e9b7a06	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-000i-9000000000-544d5b027d322e9b7a06	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-000i-9000000000-544d5b027d322e9b7a06	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-000i-9000000000-1a5edb15988820bf46f7	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-000i-9000000000-79404da79119ad6ba660	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-000i-9000000000-f83e1ccbb9745637eb97	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-000i-9000000000-348e151611d5b46f3a33	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-ITFT , positive	splash10-000i-9000000000-8c4547384f2bc29d797b	2017-09-14	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-9000000000-bd6d487d25b0e623403e	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-9000000000-d9b236846b0611684014	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-00ku-9000000000-508b10b77d98c3915247	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-001i-9000000000-b616957223f2d18551fd	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-001i-9000000000-a2e05ca3b5d63ce6a366	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-015c-9000000000-49c805d2b27473cc8f88	2016-08-03	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 400 MHz, CDCl₃, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 25.16 MHz, CDCl₃, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Spectrum

Pathways

Not Available

Protein Targets

Enzymes

Not Available

Transporters

Not Available

Metal Bindings

Not Available

Receptors

Not Available

Transcriptional Factors

Not Available

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0034301

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Not Available

Wikipedia Link

Piperidine

METLIN ID

Not Available

PubChem Compound

8082

PDB ID

PIP

ChEBI ID

18049

References

General References

Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]
Vitaku E, Smith DT, Njardarson JT: Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals. J Med Chem. 2014 Dec 26;57(24):10257-74. doi: 10.1021/jm501100b. Epub 2014 Oct 7. [PubMed:25255204 ]

Showing Compound Card for Piperidine (CDB000075)

Structure for CDB000075 (Piperidine)