Cannabis Compound Database: Showing Compound Card for Coenzyme A (CDB005096)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (176)transporters (6) Show 257 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 19:08:55 UTC

Updated at

2020-11-18 16:39:20 UTC

CannabisDB ID

CDB005096

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Coenzyme A

Description

Coenzyme A, also known as CoA-SH or coenzym a, belongs to the class of organic compounds known as coenzyme a and derivatives. These are derivative of vitamin B5 containing a 4'-phosphopantetheine moiety attached to a diphospho-adenosine. Coenzyme A is a strong basic compound (based on its pKa). Coenzyme A exists in all living species, ranging from bacteria to humans. In humans, coenzyme A is involved in the metabolic disorder called isovaleric aciduria. A thiol comprising a panthothenate unit in phosphoric anhydride linkage with a 3',5'-adenosine diphosphate unit; and an aminoethanethiol unit. Coenzyme A is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
3'-Phosphoadenosine-(5')diphospho(4')pantatheine	ChEBI
[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate	ChEBI
CoA	ChEBI
CoA-SH	ChEBI
CoASH	ChEBI
Coenzym a	ChEBI
HSCoA	ChEBI
Koenzym a	ChEBI
[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)-2,2-dimethyl-4-oxobutyl dihydrogen diphosphoric acid	Generator
[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-4-({3-oxo-3-[(2-sulphanylethyl)amino]propyl}amino)-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate	Generator
[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-4-({3-oxo-3-[(2-sulphanylethyl)amino]propyl}amino)-2,2-dimethyl-4-oxobutyl dihydrogen diphosphoric acid	Generator
a, Coenzyme	HMDB
18-CoA-18-oxo-Dinor-LTB4	HMDB
Acetoacetyl coenzyme A sodium salt	HMDB
CoA Hydrate	HMDB
coenzyme A Hydrate	HMDB
coenzyme A-SH	HMDB
coenzyme ASH	HMDB
Depot-zeel	HMDB
Propionyl CoA	HMDB
Propionyl coenzyme A	HMDB
S-Propanoate	HMDB
S-Propanoate CoA	HMDB
S-Propanoate coenzyme A	HMDB
S-Propanoic acid	HMDB
S-Propionate CoA	HMDB
S-Propionate coenzyme A	HMDB
Zeel	HMDB
Coenzyme A	HMDB

Chemical Formula

C₂₁H₃₆N₇O₁₆P₃S

Average Molecular Weight

767.53

Monoisotopic Molecular Weight

767.1152

IUPAC Name

{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid

Traditional Name

coenzyme A

CAS Registry Number

85-61-0

SMILES

CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS

InChI Identifier

InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16+,20-/m1/s1

InChI Key

RGJOEKWQDUBAIZ-IBOSZNHHSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as coenzyme a and derivatives. These are derivative of vitamin B5 containing a 4'-phosphopantetheine moiety attached to a diphospho-adenosine.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleotides

Sub Class

Purine ribonucleotides

Direct Parent

Coenzyme A and derivatives

Alternative Parents

Substituents

Coenzyme a or derivatives
Purine ribonucleoside diphosphate
Pentose phosphate
Pentose-5-phosphate
Ribonucleoside 3'-phosphate
Glycosyl compound
N-glycosyl compound
Organic pyrophosphate
Pentose monosaccharide
Monosaccharide phosphate
6-aminopurine
Purine
Imidazopyrimidine
Aminopyrimidine
Monoalkyl phosphate
Organic phosphoric acid derivative
N-substituted imidazole
Phosphoric acid ester
Monosaccharide
Alkyl phosphate
Pyrimidine
Imidolactam
Imidazole
Azole
Heteroaromatic compound
Tetrahydrofuran
Secondary alcohol
Oxacycle
Alkylthiol
Azacycle
Organoheterocyclic compound
Carboximidic acid
Carboximidic acid derivative
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Organooxygen compound
Alcohol
Hydrocarbon derivative
Organic nitrogen compound
Organic oxide
Primary amine
Organopnictogen compound
Organic oxygen compound
Amine
Organosulfur compound
Organonitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

adenosine 3',5'-bisphosphate (CHEBI:15346 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Plant:

Animal

Biological location:

Tissue and substructures:

Cell and elements:

Cell:

Fibroblast

Subcellular:

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.61	ALOGPS
logP	-5.7	ChemAxon
logS	-2.2	ALOGPS
pKa (Strongest Acidic)	0.82	ChemAxon
pKa (Strongest Basic)	4.01	ChemAxon
Physiological Charge	-4	ChemAxon
Hydrogen Acceptor Count	16	ChemAxon
Hydrogen Donor Count	10	ChemAxon
Polar Surface Area	346.56 Å²	ChemAxon
Rotatable Bond Count	18	ChemAxon
Refractivity	162.74 m³·mol⁻¹	ChemAxon
Polarizability	68.21 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Coenzyme A, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0002-9423572000-e15b71f4fd7a2baa5a35	Spectrum
Predicted GC-MS	Coenzyme A, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TMS_1_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TMS_1_7, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TMS_1_8, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TMS_1_9, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TBDMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TBDMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TBDMS_1_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TBDMS_1_7, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TBDMS_1_8, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Coenzyme A, TBDMS_1_9, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-014i-0000000900-7edeffc9e7f47049c6af	2018-05-25	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-03di-0090200000-1bf2c11b25a8c3f528a7	2018-05-25	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-03di-0490000000-b4270769e635660752dd	2018-05-25	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-0a6r-2212902000-90ae348579cc51120a9e	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-056r-2001913000-b50d7e024246e80562d9	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Positive	splash10-03dr-2970000000-d446bfcc9dc430d6289c	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Positive	splash10-03dr-2970000000-b09a59c82e4780263c01	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Positive	splash10-03dr-2980000000-0f9145a37f1fe6c25789	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Positive	splash10-03dr-2980000000-c04f72a5a1e904c02c8c	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-002r-3231905000-7feca024619c398caf0d	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-0ar9-1113901000-3774706f7a17e67cc2f1	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-0570-1011905000-6c36de994b497dccd8ba	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-056r-6432945000-c7d34ae368afb7dbd191	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-0a6r-0101911000-5229e294fd6d738ddaa1	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-05xr-2232900000-328eaaff239ce5710aae	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-052f-9437224000-1fef511bd1614c4cc9cf	2021-09-20	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-002s-5900000100-c920e6430f49f066a644	2017-07-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-002r-6910000000-4dcac54e50dd5309af5c	2017-07-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-002r-8900000000-c9fc1dcc0fa2fecbf2f0	2017-07-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-001i-6910232700-7e01b474d15249f13f3e	2017-07-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-001i-2900200000-23c6af6438be416c3b4e	2017-07-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-057i-6900100000-a9a1d2f2162117f6ad81	2017-07-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-014i-0300000900-b51e1ead5363c1a242a1	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-01p9-2940000200-3787799719117e40b9fb	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03di-1190000000-77d7b4bac6b436184da2	2021-09-24	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phenylacetate Metabolism
Butyrate Metabolism
Fatty acid Metabolism
Citric Acid Cycle
Bile Acid Biosynthesis

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
ATP-citrate synthase	ACLY	17q21.2	P53396	details
Histone acetyltransferase p300	EP300	22q13.2	Q09472	details
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	3p21.1-p14.2	P11177	details
Acetyl-CoA acetyltransferase, cytosolic	ACAT2	6q25.3	Q9BWD1	details
Diamine acetyltransferase 2	SAT2	17p13.1	Q96F10	details
5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	Xp11.21	P22557	details
Arylamine N-acetyltransferase 1	NAT1	8p22	P18440	details
Arylamine N-acetyltransferase 2	NAT2	8p22	P11245	details
5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	3p21.1	P13196	details
General transcription factor 3C polypeptide 4	GTF3C4	9q34.13	Q9UKN8	details
Acyl-coenzyme A thioesterase 12	ACOT12	5q14.1	Q8WYK0	details
Choline O-acetyltransferase	CHAT	10q11.2	P28329	details
Nuclear receptor coactivator 3	NCOA3	20q12	Q9Y6Q9	details
Histone acetyltransferase KAT2B	KAT2B	3p24	Q92831	details
Carnitine O-acetyltransferase	CRAT	9q34.1	P43155	details
Diamine acetyltransferase 1	SAT1	Xp22.1	P21673	details
Serotonin N-acetyltransferase	AANAT	17q25	Q16613	details
3-ketoacyl-CoA thiolase, mitochondrial	ACAA2	18q21.1	P42765	details
Testis-specific chromodomain protein Y 1	CDY1	Yq11.23	Q9Y6F8	details
Fatty acid synthase	FASN	17q25	P49327	details
Histone acetyltransferase KAT5	KAT5	11q13	Q92993	details
Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	20q11.22	Q9NR19	details
Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	11q22.3	P24752	details
Nuclear receptor coactivator 1	NCOA1	2p23	Q15788	details
Hydroxymethylglutaryl-CoA synthase, mitochondrial	HMGCS2	1p13-p12	P54868	details
Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	20p11.23-p11.21	Q9NUB1	details
Citrate synthase, mitochondrial	CS	12q13.2	O75390	details
Testis-specific chromodomain protein Y 2	CDY2A	Yq11.221	Q9Y6F7	details
3-ketoacyl-CoA thiolase, peroxisomal	ACAA1	3p22.2	P09110	details
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	PDHA1	Xp22.1	P08559	details
Trifunctional enzyme subunit beta, mitochondrial	HADHB	2p23	P55084	details
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	22q13.1	O75600	details
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial	PDHA2	4q22-q23	P29803	details
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	14q24.3	Q02252	details
Glucosamine 6-phosphate N-acetyltransferase	GNPNAT1	14q22.1	Q96EK6	details
Hydroxymethylglutaryl-CoA synthase, cytoplasmic	HMGCS1	5p14-p13	Q01581	details
Dihydrolipoyl dehydrogenase, mitochondrial	DLD	7q31-q32	P09622	details
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	11q23.1	P10515	details
Diacylglycerol O-acyltransferase 1	DGAT1	8q24.3	O75907	details
Peroxisomal carnitine O-octanoyltransferase	CROT	7q21.1	Q9UKG9	details
Carnitine O-palmitoyltransferase 1, muscle isoform	CPT1B	22q13.33	Q92523	details
Carnitine O-palmitoyltransferase 1, liver isoform	CPT1A	11q13.2	P50416	details
Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	1p32	P23786	details
Carnitine O-palmitoyltransferase 1, brain isoform	CPT1C	19q13.33	Q8TCG5	details
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial	MCAT	22q13.31	Q8IVS2	details
2-oxoglutarate dehydrogenase, mitochondrial	OGDH	7p14-p13	Q02218	details
Non-specific lipid-transfer protein	SCP2	1p32	P22307	details
Sterol O-acyltransferase 2	SOAT2	12q13.13	O75908	details
Sterol O-acyltransferase 1	SOAT1	1q25	P35610	details
N-acetylglutamate synthase, mitochondrial	NAGS	17q21.31	Q8N159	details
Bile acid-CoA:amino acid N-acyltransferase	BAAT	9q22.3	Q14032	details
Long-chain-fatty-acid--CoA ligase 4	ACSL4	Xq22.3-q23	O60488	details
Long-chain-fatty-acid--CoA ligase 1	ACSL1	4q35	P33121	details
Long-chain-fatty-acid--CoA ligase 6	ACSL6	5q31	Q9UKU0	details
Long-chain-fatty-acid--CoA ligase 5	ACSL5	10q25.1-q25.2	Q9ULC5	details
Long-chain-fatty-acid--CoA ligase 3	ACSL3	2q34-q35	O95573	details
Glycerol-3-phosphate acyltransferase 1, mitochondrial	GPAM	10q25.2	Q9HCL2	details
Serine palmitoyltransferase 1	SPTLC1	9q22.2	O15269	details
Serine palmitoyltransferase 2	SPTLC2	14q24.3	O15270	details
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	SUCLG1	2p11.2	P53597	details
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial	SUCLG2	3p14.1	Q96I99	details
3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	5q13.3-q14	P04035	details
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial	DLST	14q24.3	P36957	details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial	SUCLA2	13q12.2-q13.3	Q9P2R7	details
Cytosolic acyl coenzyme A thioester hydrolase	ACOT7	1p36	O00154	details
Acyl-coenzyme A thioesterase 2, mitochondrial	ACOT2	14q24.3	P49753	details
Acyl-coenzyme A thioesterase 4	ACOT4	14q24.3	Q8N9L9	details
Acyl-coenzyme A thioesterase 8	ACOT8	20q13.12	O14734	details
Palmitoyl-protein thioesterase 1	PPT1	1p32	P50897	details
Lysosomal thioesterase PPT2	PPT2		Q9UMR5	details
Dihydroxyacetone phosphate acyltransferase	GNPAT	1q42	O15228	details
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma	AGPAT3	21q22.3	Q9NRZ7	details
Glycylpeptide N-tetradecanoyltransferase 1	NMT1	17q21.31	P30419	details
1-acyl-sn-glycerol-3-phosphate acyltransferase beta	AGPAT2	9q34.3	O15120	details
Glycylpeptide N-tetradecanoyltransferase 2	NMT2	10p13	O60551	details
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha	AGPAT1	6p21.3	Q99943	details
Bifunctional coenzyme A synthase	COASY	17q12-q21	Q13057	details
Very long-chain acyl-CoA synthetase	SLC27A2	15q21.2	O14975	details
Histone acetyltransferase KAT2A	KAT2A	17q21	Q92830	details
Ceramide synthase 1	CERS1		P27544	details
Phosphatidylinositol-glycan biosynthesis class W protein	PIGW		Q7Z7B1	details
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon	AGPAT5	8p23.1	Q9NUQ2	details
Bile acyl-CoA synthetase	SLC27A5	19q13.43	Q9Y2P5	details
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial	DBT	1p31	P11182	details
2-acylglycerol O-acyltransferase 2	MOGAT2	11q13.5	Q3SYC2	details
Glycerol-3-phosphate acyltransferase 4	AGPAT6	8p11.21	Q86UL3	details
Acetoacetyl-CoA synthetase	AACS	12q24.31	Q86V21	details
Acyl-coenzyme A synthetase ACSM1, mitochondrial	ACSM1	16p12.3	Q08AH1	details
Elongation of very long chain fatty acids protein 4	ELOVL4	6q14	Q9GZR5	details
Diacylglycerol O-acyltransferase 2	DGAT2	11q13.5	Q96PD7	details
1-acyl-sn-glycerol-3-phosphate acyltransferase delta	AGPAT4	6q26	Q9NRZ5	details
2-acylglycerol O-acyltransferase 1	MOGAT1	2q36.1	Q96PD6	details
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	2q32.2	Q6NVY1	details
Fatty acyl-CoA reductase 1	FAR1	11p15.2	Q8WVX9	details
Fatty acyl-CoA reductase 2	FAR2	12p11.22	Q96K12	details
Acyl-CoA wax alcohol acyltransferase 1	AWAT1	Xq13.1	Q58HT5	details
Acyl-CoA wax alcohol acyltransferase 2	AWAT2	Xq13.1	Q6E213	details
2-acylglycerol O-acyltransferase 3	MOGAT3	7q22.1	Q86VF5	details
Lysophospholipid acyltransferase 5	LPCAT3	12p13	Q6P1A2	details
Lysophosphatidylcholine acyltransferase 1	LPCAT1	5p15.33	Q8NF37	details
Lysophosphatidylcholine acyltransferase 2	LPCAT2	16q12.2	Q7L5N7	details
Lysocardiolipin acyltransferase 1	LCLAT1	2p23.1	Q6UWP7	details
Glycerol-3-phosphate acyltransferase 3	AGPAT9	4q21.23	Q53EU6	details
Glycine N-acyltransferase	GLYAT	11q12.1	Q6IB77	details
Glycine N-acyltransferase-like protein 1	GLYATL1	11q12.1	Q969I3	details
Glycine N-acyltransferase-like protein 2	GLYATL2	11q12.1	Q8WU03	details
ACSS2 protein	ACSS2	20q11.22	Q96FY7	details
Acyl-coenzyme A synthetase ACSM6, mitochondrial	ACSM6	10q23.33	Q6P461	details
Acyl-coenzyme A synthetase ACSM2A, mitochondrial	ACSM2A	16p12.3	Q08AH3	details
Acyl-coenzyme A synthetase ACSM2B, mitochondrial	ACSM2B	16p12.3	Q68CK6	details
Acyl-coenzyme A synthetase ACSM3, mitochondrial	ACSM3	16p13.11	Q53FZ2	details
Acyl-coenzyme A synthetase ACSM5, mitochondrial	ACSM5	16p12.3	Q6NUN0	details
Serine palmitoyltransferase 3	SPTLC3	20p12.1	Q9NUV7	details
2-oxoglutarate dehydrogenase-like, mitochondrial	OGDHL		Q9ULD0	details
Acyl-coenzyme A synthetase ACSM4, mitochondrial	ACSM4	12p13.31	P0C7M7	details
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial	OXSM	3p24.2	Q9NWU1	details
1-acylglycerol-3-phosphate O-acyltransferase 6 (Lysophosphatidic acid acyltransferase, zeta), isoform CRA_b	AGPAT6	8p11.21	Q2TU73	details
Histone acetyltransferase KAT6B	KAT6B	10q22.2	Q8WYB5	details
MYST3 protein	MYST3	8p11	A5PKX7	details
Histone acetyltransferase KAT8	KAT8	16p11.2	Q9H7Z6	details
Histone acetyltransferase type B catalytic subunit	HAT1	2q31.2-q33.1	O14929	details
Malonyl CoA:ACP acyltransferase (Mitochondrial)	MCAT	22q13.31	B0QY72	details
Glycerol-3-phosphate acyltransferase 2, mitochondrial	GPAT2	2q11.1	Q6NUI2	details
Chromodomain Y-like protein	CDYL	6p25.1	Q9Y232	details
Ceramide synthase 5	CERS5		Q8N5B7	details
Acyl-coenzyme A thioesterase 1	ACOT1	14q24.3	Q86TX2	details
Cytosolic acyl coenzyme A thioester hydrolase-like	ACOT7L		Q6ZUV0	details
Long-chain-fatty-acid--CoA ligase ACSBG2	ACSBG2	19p13.3	Q5FVE4	details
Long-chain-fatty-acid--CoA ligase ACSBG1	ACSBG1	15q23-q24	Q96GR2	details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	AASDHPPT	11q22	Q9NRN7	details
Circadian locomoter output cycles protein kaput	CLOCK	4q12	O15516	details
Histone acetyltransferase KAT7	KAT7	17q21.32	O95251	details
1-acylglycerol-3-phosphate O-acyltransferase ABHD5	ABHD5	3p21	Q8WTS1	details
Acyl-coenzyme A thioesterase THEM5	THEM5	1q21.3	Q8N1Q8	details
Acyl-CoA synthetase short-chain family member 3, mitochondrial	ACSS3	12q21.31	Q9H6R3	details
Alpha-tubulin N-acetyltransferase	ATAT1	6p21.33	Q5SQI0	details
Ceramide synthase 2	CERS2		Q96G23	details
Ceramide synthase 3	CERS3		Q8IU89	details
Ceramide synthase 4	CERS4		Q9HA82	details
Ceramide synthase 6	CERS6		Q6ZMG9	details
Heparan-alpha-glucosaminide N-acetyltransferase	HGSNAT	8p11.1	Q68CP4	details
Histone acetyltransferase KAT6A	KAT6A	8p11	Q92794	details
Lysophospholipid acyltransferase 1	MBOAT1	6p22.3	Q6ZNC8	details
Lysophospholipid acyltransferase 2	MBOAT2	2p25.1	Q6ZWT7	details
Lysophospholipid acyltransferase 7	MBOAT7	19q13.4	Q96N66	details
N-alpha-acetyltransferase 10	NAA10	Xq28	P41227	details
N-alpha-acetyltransferase 11	NAA11	4q21.21	Q9BSU3	details
N-alpha-acetyltransferase 20	NAA20	20p11.23	P61599	details
N-alpha-acetyltransferase 30	NAA30	14q22.3	Q147X3	details
N-alpha-acetyltransferase 60	NAA60	16p13.3	Q9H7X0	details
N-acetylaspartate synthetase	NAT8L	4p16.3	Q8N9F0	details
Acyl-coenzyme A thioesterase THEM4	THEM4	1q21	Q5T1C6	details
Probable palmitoyltransferase ZDHHC11	ZDHHC11	5p15.33	Q9H8X9	details
Probable palmitoyltransferase ZDHHC12	ZDHHC12	9q34.11	Q96GR4	details
Palmitoyltransferase ZDHHC13	ZDHHC13	11p15.1	Q8IUH4	details
Probable palmitoyltransferase ZDHHC14	ZDHHC14	6q25.3	Q8IZN3	details
Palmitoyltransferase ZDHHC15	ZDHHC15	Xq13.3	Q96MV8	details
Probable palmitoyltransferase ZDHHC16	ZDHHC16	10q24.1	Q969W1	details
Palmitoyltransferase ZDHHC17	ZDHHC17	12q21.2	Q8IUH5	details
Palmitoyltransferase ZDHHC18	ZDHHC18	1p36.11	Q9NUE0	details
Probable palmitoyltransferase ZDHHC19	ZDHHC19	3q29	Q8WVZ1	details
Probable palmitoyltransferase ZDHHC20	ZDHHC20	13q12.11	Q5W0Z9	details
Palmitoyltransferase ZDHHC21	ZDHHC21	9p22.3	Q8IVQ6	details
Putative palmitoyltransferase ZDHHC22	ZDHHC22	14q24.3	Q8N966	details
Probable palmitoyltransferase ZDHHC23	ZDHHC23	3q13.31	Q8IYP9	details
Probable palmitoyltransferase ZDHHC24	ZDHHC24	11q13.2	Q6UX98	details
Probable palmitoyltransferase ZDHHC1	ZDHHC1	16q22.1	Q8WTX9	details
Palmitoyltransferase ZDHHC2	ZDHHC2	8p22	Q9UIJ5	details
Palmitoyltransferase ZDHHC3	ZDHHC3	3p21.31	Q9NYG2	details
Probable palmitoyltransferase ZDHHC4	ZDHHC4	7p22.1	Q9NPG8	details
Palmitoyltransferase ZDHHC5	ZDHHC5	11q12.1	Q9C0B5	details
Palmitoyltransferase ZDHHC6	ZDHHC6	10q25.2	Q9H6R6	details
Palmitoyltransferase ZDHHC7	ZDHHC7	16q24.1	Q9NXF8	details
Probable palmitoyltransferase ZDHHC8	ZDHHC8	22q11.21	Q9ULC8	details
Palmitoyltransferase ZDHHC9	ZDHHC9	Xq26.1	Q9Y397	details
Probable palmitoyltransferase ZDHHC11B	ZDHHC11B		P0C7U3	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Fatty acid synthase	FASN	17q25	P49327	details
Non-specific lipid-transfer protein	SCP2	1p32	P22307	details
Very long-chain acyl-CoA synthetase	SLC27A2	15q21.2	O14975	details
Bile acyl-CoA synthetase	SLC27A5	19q13.43	Q9Y2P5	details
Palmitoyltransferase ZDHHC13	ZDHHC13	11p15.1	Q8IUH4	details
Palmitoyltransferase ZDHHC17	ZDHHC17	12q21.2	Q8IUH5	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
ATP-citrate synthase	ACLY	17q21.2	P53396	details
Histone acetyltransferase p300	EP300	22q13.2	Q09472	details
CREB-binding protein	CREBBP	16p13.3	Q92793	details
Fatty acid synthase	FASN	17q25	P49327	details
Histone acetyltransferase KAT5	KAT5	11q13	Q92993	details
Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	11q22.3	P24752	details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial	SUCLA2	13q12.2-q13.3	Q9P2R7	details
Acyl-coenzyme A synthetase ACSM1, mitochondrial	ACSM1	16p12.3	Q08AH1	details
Lysophosphatidylcholine acyltransferase 1	LPCAT1	5p15.33	Q8NF37	details
Lysophosphatidylcholine acyltransferase 2	LPCAT2	16q12.2	Q7L5N7	details
Acyl-coenzyme A synthetase ACSM6, mitochondrial	ACSM6	10q23.33	Q6P461	details
Acyl-coenzyme A synthetase ACSM2A, mitochondrial	ACSM2A	16p12.3	Q08AH3	details
Acyl-coenzyme A synthetase ACSM2B, mitochondrial	ACSM2B	16p12.3	Q68CK6	details
Acyl-coenzyme A synthetase ACSM3, mitochondrial	ACSM3	16p13.11	Q53FZ2	details
Acyl-coenzyme A synthetase ACSM5, mitochondrial	ACSM5	16p12.3	Q6NUN0	details
Elongator complex protein 3	ELP3	8p21.1	Q9H9T3	details
Acyl-coenzyme A synthetase ACSM4, mitochondrial	ACSM4	12p13.31	P0C7M7	details
Histone acetyltransferase KAT6B	KAT6B	10q22.2	Q8WYB5	details
MYST3 protein	MYST3	8p11	A5PKX7	details
Histone acetyltransferase KAT8	KAT8	16p11.2	Q9H7Z6	details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	AASDHPPT	11q22	Q9NRN7	details
Histone acetyltransferase KAT7	KAT7	17q21.32	O95251	details
Histone acetyltransferase KAT6A	KAT6A	8p11	Q92794	details
Probable palmitoyltransferase ZDHHC11	ZDHHC11	5p15.33	Q9H8X9	details
Probable palmitoyltransferase ZDHHC12	ZDHHC12	9q34.11	Q96GR4	details
Palmitoyltransferase ZDHHC13	ZDHHC13	11p15.1	Q8IUH4	details
Probable palmitoyltransferase ZDHHC14	ZDHHC14	6q25.3	Q8IZN3	details
Palmitoyltransferase ZDHHC15	ZDHHC15	Xq13.3	Q96MV8	details
Probable palmitoyltransferase ZDHHC16	ZDHHC16	10q24.1	Q969W1	details
Palmitoyltransferase ZDHHC17	ZDHHC17	12q21.2	Q8IUH5	details
Palmitoyltransferase ZDHHC18	ZDHHC18	1p36.11	Q9NUE0	details
Probable palmitoyltransferase ZDHHC19	ZDHHC19	3q29	Q8WVZ1	details
Probable palmitoyltransferase ZDHHC20	ZDHHC20	13q12.11	Q5W0Z9	details
Palmitoyltransferase ZDHHC21	ZDHHC21	9p22.3	Q8IVQ6	details
Putative palmitoyltransferase ZDHHC22	ZDHHC22	14q24.3	Q8N966	details
Probable palmitoyltransferase ZDHHC23	ZDHHC23	3q13.31	Q8IYP9	details
Probable palmitoyltransferase ZDHHC24	ZDHHC24	11q13.2	Q6UX98	details
Probable palmitoyltransferase ZDHHC1	ZDHHC1	16q22.1	Q8WTX9	details
Palmitoyltransferase ZDHHC2	ZDHHC2	8p22	Q9UIJ5	details
Palmitoyltransferase ZDHHC3	ZDHHC3	3p21.31	Q9NYG2	details
Probable palmitoyltransferase ZDHHC4	ZDHHC4	7p22.1	Q9NPG8	details
Palmitoyltransferase ZDHHC5	ZDHHC5	11q12.1	Q9C0B5	details
Palmitoyltransferase ZDHHC6	ZDHHC6	10q25.2	Q9H6R6	details
Palmitoyltransferase ZDHHC7	ZDHHC7	16q24.1	Q9NXF8	details
Probable palmitoyltransferase ZDHHC8	ZDHHC8	22q11.21	Q9ULC8	details
Palmitoyltransferase ZDHHC9	ZDHHC9	Xq26.1	Q9Y397	details
Probable palmitoyltransferase ZDHHC11B	ZDHHC11B		P0C7U3	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Histone acetyltransferase p300	EP300	22q13.2	Q09472	details
Nuclear receptor coactivator 3	NCOA3	20q12	Q9Y6Q9	details
Histone acetyltransferase KAT5	KAT5	11q13	Q92993	details
Nuclear receptor coactivator 1	NCOA1	2p23	Q15788	details
Palmitoyl-protein thioesterase 1	PPT1	1p32	P50897	details
Elongation of very long chain fatty acids protein 4	ELOVL4	6q14	Q9GZR5	details
Acyl-coenzyme A thioesterase THEM4	THEM4	1q21	Q5T1C6	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Histone acetyltransferase p300	EP300	22q13.2	Q09472	details
CREB-binding protein	CREBBP	16p13.3	Q92793	details
General transcription factor 3C polypeptide 4	GTF3C4	9q34.13	Q9UKN8	details
Nuclear receptor coactivator 3	NCOA3	20q12	Q9Y6Q9	details
Histone acetyltransferase KAT2B	KAT2B	3p24	Q92831	details
Histone acetyltransferase KAT5	KAT5	11q13	Q92993	details
Nuclear receptor coactivator 1	NCOA1	2p23	Q15788	details
Histone acetyltransferase KAT2A	KAT2A	17q21	Q92830	details
Elongator complex protein 3	ELP3	8p21.1	Q9H9T3	details
Histone acetyltransferase KAT6B	KAT6B	10q22.2	Q8WYB5	details
MYST3 protein	MYST3	8p11	A5PKX7	details
Histone acetyltransferase KAT8	KAT8	16p11.2	Q9H7Z6	details
Chromodomain Y-like protein	CDYL	6p25.1	Q9Y232	details
Ceramide synthase 5	CERS5		Q8N5B7	details
Circadian locomoter output cycles protein kaput	CLOCK	4q12	O15516	details
Histone acetyltransferase KAT7	KAT7	17q21.32	O95251	details
Ceramide synthase 2	CERS2		Q96G23	details
Ceramide synthase 3	CERS3		Q8IU89	details
Ceramide synthase 4	CERS4		Q9HA82	details
Ceramide synthase 6	CERS6		Q6ZMG9	details
Histone acetyltransferase KAT6A	KAT6A	8p11	Q92794	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0001423

DrugBank ID

DB01992

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Not Available

Wikipedia Link

Coenzyme_A

METLIN ID

Not Available

PubChem Compound

87642

PDB ID

Not Available

ChEBI ID

15346

References

General References

Not Available

Only showing the first 10 proteins. There are 257 proteins in total.

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Enzymes

Enzyme Details

1. ATP-citrate synthase

General function:: Involved in ATP citrate synthase activity
Specific function:: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
Gene Name:: ACLY
Uniprot ID:: P53396
Molecular weight:: 120838.27

Enzyme Details

2. Histone acetyltransferase p300

General function:: Involved in transcription cofactor activity
Specific function:: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity.
Gene Name:: EP300
Uniprot ID:: Q09472
Molecular weight:: 264159.725

Enzyme Details

3. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

General function:: Involved in catalytic activity
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHB
Uniprot ID:: P11177
Molecular weight:: 39233.1

Enzyme Details

4. Acetyl-CoA acetyltransferase, cytosolic

General function:: Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:: Not Available
Gene Name:: ACAT2
Uniprot ID:: Q9BWD1
Molecular weight:: 41350.5

Enzyme Details

5. Diamine acetyltransferase 2

General function:: Involved in N-acetyltransferase activity
Specific function:: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.
Gene Name:: SAT2
Uniprot ID:: Q96F10
Molecular weight:: 19154.905

Enzyme Details

6. 5-aminolevulinate synthase, erythroid-specific, mitochondrial

General function:: Involved in 5-aminolevulinate synthase activity
Specific function:: Not Available
Gene Name:: ALAS2
Uniprot ID:: P22557
Molecular weight:: 64632.86

Enzyme Details

7. Arylamine N-acetyltransferase 1

General function:: Involved in acetyltransferase activity
Specific function:: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Gene Name:: NAT1
Uniprot ID:: P18440
Molecular weight:: 33898.445

Enzyme Details

8. Arylamine N-acetyltransferase 2

General function:: Involved in acetyltransferase activity
Specific function:: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Gene Name:: NAT2
Uniprot ID:: P11245
Molecular weight:: 33570.245

Enzyme Details

9. 5-aminolevulinate synthase, nonspecific, mitochondrial

General function:: Involved in 5-aminolevulinate synthase activity
Specific function:: Not Available
Gene Name:: ALAS1
Uniprot ID:: P13196
Molecular weight:: 70580.325

Enzyme Details

10. General transcription factor 3C polypeptide 4

General function:: Involved in DNA binding
Specific function:: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.
Gene Name:: GTF3C4
Uniprot ID:: Q9UKN8
Molecular weight:: 91981.635

Transporters

Enzyme Details

1. Fatty acid synthase

General function:: Involved in transferase activity
Specific function:: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
Gene Name:: FASN
Uniprot ID:: P49327
Molecular weight:: 273424.06

Enzyme Details

2. Non-specific lipid-transfer protein

General function:: Involved in oxidoreductase activity
Specific function:: Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
Gene Name:: SCP2
Uniprot ID:: P22307
Molecular weight:: 34974.505

Enzyme Details

3. Very long-chain acyl-CoA synthetase

General function:: Involved in catalytic activity
Specific function:: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
Gene Name:: SLC27A2
Uniprot ID:: O14975
Molecular weight:: 64614.99

Enzyme Details

4. Bile acyl-CoA synthetase

General function:: Involved in catalytic activity
Specific function:: Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
Gene Name:: SLC27A5
Uniprot ID:: Q9Y2P5
Molecular weight:: 75384.375

Enzyme Details

5. Palmitoyltransferase ZDHHC13

General function:: Not Available
Specific function:: Palmitoyltransferase for HD and GAD2 (By similarity). Mediates Mg(2+) transport (By similarity).
Gene Name:: ZDHHC13
Uniprot ID:: Q8IUH4
Molecular weight:: 56508.075

Enzyme Details

6. Palmitoyltransferase ZDHHC17

General function:: Not Available
Specific function:: Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport.
Gene Name:: ZDHHC17
Uniprot ID:: Q8IUH5
Molecular weight:: 72639.345

Only showing the first 10 proteins. There are 257 proteins in total.

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Showing Compound Card for Coenzyme A (CDB005096)

Structure for CDB005096 (Coenzyme A)

Enzymes

Transporters